TY - JOUR
T1 - The potential role of iodine-123 metaiodobenzylguanidine imaging for identifying sustained ventricular tachycardia in patients with cardiomyopathy.
AU - Klein, Thomas
AU - Dilsizian, Vasken
AU - Cao, Q.
AU - Chen, Wengen
AU - Dickfeld, Timm Michael
PY - 2013/5
Y1 - 2013/5
N2 - Implantable cardioverter-defibrillators (ICDs) significantly reduce mortality in patients with depressed left ventricular ejection fraction (LVEF) and heart failure (HF). However, shortcomings of LVEF to accurately identify those at greatest risk of ventricular tachyarrhythmias have led to the pursuit of alternative means to refine qualification criteria for ICD implantation. It is well established that imaging the cardiac nervous system with(123)I meta-iodobenzylguanidine ((123)I-mIBG) provides incremental prognostic value in patients with HF beyond LVEF. Whether (123)I-mIBG will also play an important role for identifying and/or predicting sustained ventricular tachyarrhythmias in patients with cardiomyopathy and determining those who may benefit from ICD implantation is currently under investigation. Novel imaging approaches that pinpoint the site of ventricular arrhythmias and guide ventricular tachycardia ablation are presented.
AB - Implantable cardioverter-defibrillators (ICDs) significantly reduce mortality in patients with depressed left ventricular ejection fraction (LVEF) and heart failure (HF). However, shortcomings of LVEF to accurately identify those at greatest risk of ventricular tachyarrhythmias have led to the pursuit of alternative means to refine qualification criteria for ICD implantation. It is well established that imaging the cardiac nervous system with(123)I meta-iodobenzylguanidine ((123)I-mIBG) provides incremental prognostic value in patients with HF beyond LVEF. Whether (123)I-mIBG will also play an important role for identifying and/or predicting sustained ventricular tachyarrhythmias in patients with cardiomyopathy and determining those who may benefit from ICD implantation is currently under investigation. Novel imaging approaches that pinpoint the site of ventricular arrhythmias and guide ventricular tachycardia ablation are presented.
UR - http://www.scopus.com/inward/record.url?scp=84884306467&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84884306467&partnerID=8YFLogxK
U2 - 10.1007/s11886-013-0359-1
DO - 10.1007/s11886-013-0359-1
M3 - Article
C2 - 23536110
AN - SCOPUS:84875283887
SN - 1523-3782
VL - 15
SP - 359
JO - Current Cardiology Reports
JF - Current Cardiology Reports
IS - 5
ER -