Abstract
Although conventional treatment strategies of drug administration and surgical intervention have been successful in protecting vision loss, however these efforts have been unable to discover a comprehensive approach to prevent the progression of disease in many ocular disorders. In this context, stem cell-based therapies provide an alternative approach to prevent vision loss in instances where conventional treatments have failed. The immune-privileged status and easy accessibility of different tissue of the eye offers several advantages for stem-cell-based therapeutic intervention. The pluripotent stem cells have been used to generate multiple eye cell types including corneal epithelial- and endothelial-cells, retinal pigment-epithelial cells, photoreceptors, retinal ganglion cells, and lens, conjunctival, limbal, and trabecular meshwork cells. Multiple pluripotent stem cell-based clinical trials for the treatment of a wide range of eye diseases are in progress. In this chapter, we review the potential of pluripotent stem cell-derived cells of multiple eye tissues to prevent vision loss by replacing the degenerative cells.
| Original language | English (US) |
|---|---|
| Title of host publication | Handbook of Stem Cell Therapy |
| Subtitle of host publication | Volume 1 |
| Publisher | Springer Nature |
| Pages | 607-624 |
| Number of pages | 18 |
| ISBN (Electronic) | 9789811926556 |
| ISBN (Print) | 9789811926549 |
| DOIs | |
| State | Published - Jan 1 2022 |
Keywords
- Embryonic stem cells
- Eye
- Induced pluripotent stem cells
- Ocular
- Preclinical
- Retinal
- Stem cells
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology
- General Medicine