The polydeoxyadenylate tract of Alu repetitive elements is polymorphic in the human genome

Effrosini P. Economou; Andrew W. Bergen; Andrew C. Warren; Stylianos E. Antonarakis

doi:10.1073/pnas.87.8.2951

The polydeoxyadenylate tract of Alu repetitive elements is polymorphic in the human genome

Effrosini P. Economou, Andrew W. Bergen, Andrew C. Warren, Stylianos E. Antonarakis

Research output: Contribution to journal › Article › peer-review

245 Scopus citations

Abstract

To identify DNA polymorphisms that are abundant in the human genome and are detectable by polymerase chain reaction amplification of genomic DNA, we tested the hypothesis that the polydeoxyadenylate tract of the Alu family of repetitive elements is polymorphic among human chromosomes. We analyzed the 3′ ends of three specific Alu sequences and found that two (in the adenosine deaminase gene and the β-globin pseudogene) were polymorphic. This novel class of polymorphisms, termed AluVpA [Alu variable poly(A)] may represent one of the most useful and informative group of DNA markers in the human genome.

Original language	English (US)
Pages (from-to)	2951-2954
Number of pages	4
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	87
Issue number	8
DOIs	https://doi.org/10.1073/pnas.87.8.2951
State	Published - Apr 1990
Externally published	Yes

Keywords

Adenosine deaminase gene
DNA marker
Polymerase chain reaction
β-globin gene cluster

ASJC Scopus subject areas

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10.1073/pnas.87.8.2951

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title = "The polydeoxyadenylate tract of Alu repetitive elements is polymorphic in the human genome",

abstract = "To identify DNA polymorphisms that are abundant in the human genome and are detectable by polymerase chain reaction amplification of genomic DNA, we tested the hypothesis that the polydeoxyadenylate tract of the Alu family of repetitive elements is polymorphic among human chromosomes. We analyzed the 3′ ends of three specific Alu sequences and found that two (in the adenosine deaminase gene and the β-globin pseudogene) were polymorphic. This novel class of polymorphisms, termed AluVpA [Alu variable poly(A)] may represent one of the most useful and informative group of DNA markers in the human genome.",

keywords = "Adenosine deaminase gene, DNA marker, Polymerase chain reaction, β-globin gene cluster",

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year = "1990",

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T1 - The polydeoxyadenylate tract of Alu repetitive elements is polymorphic in the human genome

AU - Economou, Effrosini P.

AU - Bergen, Andrew W.

AU - Warren, Andrew C.

AU - Antonarakis, Stylianos E.

PY - 1990/4

Y1 - 1990/4

N2 - To identify DNA polymorphisms that are abundant in the human genome and are detectable by polymerase chain reaction amplification of genomic DNA, we tested the hypothesis that the polydeoxyadenylate tract of the Alu family of repetitive elements is polymorphic among human chromosomes. We analyzed the 3′ ends of three specific Alu sequences and found that two (in the adenosine deaminase gene and the β-globin pseudogene) were polymorphic. This novel class of polymorphisms, termed AluVpA [Alu variable poly(A)] may represent one of the most useful and informative group of DNA markers in the human genome.

AB - To identify DNA polymorphisms that are abundant in the human genome and are detectable by polymerase chain reaction amplification of genomic DNA, we tested the hypothesis that the polydeoxyadenylate tract of the Alu family of repetitive elements is polymorphic among human chromosomes. We analyzed the 3′ ends of three specific Alu sequences and found that two (in the adenosine deaminase gene and the β-globin pseudogene) were polymorphic. This novel class of polymorphisms, termed AluVpA [Alu variable poly(A)] may represent one of the most useful and informative group of DNA markers in the human genome.

KW - Adenosine deaminase gene

KW - DNA marker

KW - Polymerase chain reaction

KW - β-globin gene cluster

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The polydeoxyadenylate tract of Alu repetitive elements is polymorphic in the human genome

Abstract

Keywords

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