The pneumonia etiology research for child health project: A 21st century childhood pneumonia etiology study

Orin S. Levine; Katherine L. O'Brien; Maria Deloria-Knoll; David R. Murdoch; Daniel R. Feikin; Andrea N. Deluca; Amanda J. Driscoll; Henry C. Baggett; W. Abdullah Brooks; Stephen R.C. Howie; Karen L. Kotloff; Shabir A. Madhi; Susan A. Maloney; Samba Sow; Donald M. Thea; J. Anthony Scott

doi:10.1093/cid/cir1052

The pneumonia etiology research for child health project: A 21st century childhood pneumonia etiology study

Orin S. Levine, Katherine L. O'Brien, Maria Deloria-Knoll, David R. Murdoch, Daniel R. Feikin, Andrea N. Deluca, Amanda J. Driscoll, Henry C. Baggett, W. Abdullah Brooks, Stephen R.C. Howie, Karen L. Kotloff, Shabir A. Madhi, Susan A. Maloney, Samba Sow, Donald M. Thea, J. Anthony Scott

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

124 Scopus citations

Abstract

The Pneumonia Etiology Research for Child Health (PERCH) project is a 7-country, standardized, comprehensive evaluation of the etiologic agents causing severe pneumonia in children from developing countries. During previous etiology studies, between one-quarter and one-third of patients failed to yield an obvious etiology; PERCH will employ and evaluate previously unavailable innovative, more sensitive diagnostic techniques. Innovative and rigorous epidemiologic and analytic methods will be used to establish the causal association between presence of potential pathogens and pneumonia. By strategic selection of study sites that are broadly representative of regions with the greatest burden of childhood pneumonia, PERCH aims to provide data that reflect the epidemiologic situation in developing countries in 2015, using pneumococcal and Haemophilus influenzae type b vaccines. PERCH will also address differences in host, environmental, and/or geographic factors that might determine pneumonia etiology and, by preserving specimens, will generate a resource for future research and pathogen discovery.

Original language	English (US)
Pages (from-to)	S93-S101
Journal	Clinical Infectious Diseases
Volume	54
Issue number	SUPPL. 2
DOIs	https://doi.org/10.1093/cid/cir1052
State	Published - Apr 1 2012

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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Levine, O. S., O'Brien, K. L., Deloria-Knoll, M., Murdoch, D. R., Feikin, D. R., Deluca, A. N., Driscoll, A. J., Baggett, H. C., Brooks, W. A., Howie, S. R. C., Kotloff, K. L., Madhi, S. A., Maloney, S. A., Sow, S., Thea, D. M., & Scott, J. A. (2012). The pneumonia etiology research for child health project: A 21st century childhood pneumonia etiology study. Clinical Infectious Diseases, 54(SUPPL. 2), S93-S101. https://doi.org/10.1093/cid/cir1052

Levine, OS, O'Brien, KL, Deloria-Knoll, M, Murdoch, DR, Feikin, DR, Deluca, AN, Driscoll, AJ, Baggett, HC, Brooks, WA, Howie, SRC, Kotloff, KL, Madhi, SA, Maloney, SA, Sow, S, Thea, DM & Scott, JA 2012, 'The pneumonia etiology research for child health project: A 21st century childhood pneumonia etiology study', Clinical Infectious Diseases, vol. 54, no. SUPPL. 2, pp. S93-S101. https://doi.org/10.1093/cid/cir1052

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abstract = "The Pneumonia Etiology Research for Child Health (PERCH) project is a 7-country, standardized, comprehensive evaluation of the etiologic agents causing severe pneumonia in children from developing countries. During previous etiology studies, between one-quarter and one-third of patients failed to yield an obvious etiology; PERCH will employ and evaluate previously unavailable innovative, more sensitive diagnostic techniques. Innovative and rigorous epidemiologic and analytic methods will be used to establish the causal association between presence of potential pathogens and pneumonia. By strategic selection of study sites that are broadly representative of regions with the greatest burden of childhood pneumonia, PERCH aims to provide data that reflect the epidemiologic situation in developing countries in 2015, using pneumococcal and Haemophilus influenzae type b vaccines. PERCH will also address differences in host, environmental, and/or geographic factors that might determine pneumonia etiology and, by preserving specimens, will generate a resource for future research and pathogen discovery.",

author = "Levine, {Orin S.} and O'Brien, {Katherine L.} and Maria Deloria-Knoll and Murdoch, {David R.} and Feikin, {Daniel R.} and Deluca, {Andrea N.} and Driscoll, {Amanda J.} and Baggett, {Henry C.} and Brooks, {W. Abdullah} and Howie, {Stephen R.C.} and Kotloff, {Karen L.} and Madhi, {Shabir A.} and Maloney, {Susan A.} and Samba Sow and Thea, {Donald M.} and Scott, {J. Anthony}",

note = "Funding Information: Supplement sponsorship. This article was published as part of a supplement entitled {\textquoteleft}{\textquoteleft}Pneumonia Etiology Research for Child Health,{\textquoteright}{\textquoteright} sponsored by a grant from The Bill & Melinda Gates Foundation to the PERCH Project of Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. Potential conflicts of interest. All authors: No reported conflicts.",

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AU - Scott, J. Anthony

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The pneumonia etiology research for child health project: A 21st century childhood pneumonia etiology study

Abstract

ASJC Scopus subject areas

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