The Plasmodium bottleneck: Malaria parasite losses in the mosquito vector

Ryan C. Smith, Joel Vega-Rodríguez, Marcelo Jacobs-Lorena

Research output: Contribution to journalArticlepeer-review

97 Scopus citations


Nearly one million people are killed every year by the malaria parasite Plasmodium. Although the disease-causing forms of the parasite exist only in the human blood, mosquitoes of the genus Anopheles are the obligate vector for transmission. Here, we review the parasite life cycle in the vector and highlight the human and mosquito contributions that limit malaria parasite development in the mosquito host. We address parasite killing in its mosquito host and bottlenecks in parasite numbers that might guide intervention strategies to prevent transmission.

Original languageEnglish (US)
Pages (from-to)644-661
Number of pages18
JournalMemorias do Instituto Oswaldo Cruz
Issue number5
StatePublished - Aug 2014
Externally publishedYes


  • Innate immunity
  • Malaria
  • Mosquito
  • Plasmodium

ASJC Scopus subject areas

  • Microbiology (medical)


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