The pharmacokinetics of pentazocine and tripelennamine

S. Y. Yeh, G. D. Todd, R. E. Johnson, C. W. Gorodetzky, W. R. Lange

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


The pharmacokinetics of single and combined doses of pentazocine HCl (40 and 80 mg) and tripelennamine HCl (50 and 100 mg) were studied in six healthy drug abusers. After intramuscular administration of 40 or 80 mg pentazocine alone, mean peak plasma concentrations at 15 minutes were 102 and 227 ng/ml, respectively, and mean plasma t( 1/2 ) values were 4.6 and 5.3 hours, respectively. After intramuscular administration of 50 or 100 mg tripelennamine, mean plasma concentrations at 30 minutes were 105 and 194 ng/ml, respectively, and mean plasma t( 1/2 ) values were 2.9 and 4.4 hours, respectively. After concurrent administration of pentazocine with tripelennamine, plasma pentazocine and tripelennamine concentrations at all time points were not significantly different from those when pentazocine or tripelennamine was administered alone. Coadministration of pentazocine and tripelennamine had no effect on the distribution, elimination, and clearance of either pentazocine or tripelennamine. In conclusion, there did not appear to be a clinically significant metabolic interaction between pentazocine and tripelennamine.

Original languageEnglish (US)
Pages (from-to)669-676
Number of pages8
JournalClinical Pharmacology and Therapeutics
Issue number6
StatePublished - 1986

ASJC Scopus subject areas

  • Pharmacology


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