The perinuclear actin cap in health and disease

Shyam B. Khatau, Dong Hwee Kim, Christopher M. Hale, Ryan J. Bloom, Denis Wirtz

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


We recently demonstrated the existence of a previously uncharacterized subset of actomyosin fibers that form the perinuclear actin cap, a cytoskeletal structure that tightly wraps around the nucleus of a wide range of somatic cells. Fibers in the actin cap are distinct from well-characterized, conventional actin fibers at the basal and dorsal surfaces of adherent cells in their subcellular location, internal organization, dynamics, ability to generate contractile forces, response to cytoskeletal pharmacological treatments, response to biochemical stimuli, regulation by components of the linkers of nucleoskeleton and cytoskeleton (LINC) complexes, and response to disease-associated mutations in LMNA, the gene that encodes for the nuclear lamin component lamin A/C. The perinuclear actin cap precisely shapes the nucleus in interphase cells. The perinuclear actin cap may also be a mediator of microenvironment mechanosensing and mechanotransduction, as well as a regulator of cell motility, polarization and differentiation.

Original languageEnglish (US)
Pages (from-to)337-342
Number of pages6
Issue number4
StatePublished - 2010


  • Actin
  • Cancer
  • Cell shape
  • LINC complexes
  • Laminopathies
  • Nuclear lamina
  • Nucleus

ASJC Scopus subject areas

  • Cell Biology


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