The pathophysiology of intervertebral disc disease

Akwasi Ofori Boah, Nancy Abu-Bonsrah, C. Rory Goodwin, Daniel Sciubba

Research output: Chapter in Book/Report/Conference proceedingChapter


The degeneration of the intervertebral disc results from several multifactorial pathophysiologic processes. Here, we discuss the anatomy of the intervertebral disc along with a presentation of several pathologic processes including vascular insufficiency (possibly due to cigarette exposure and endothelial dysfunction), anatomic variations, poor nutritional status, infections, autoimmune and/or inflammatory processes, genetic predispositions and iatrogenic occurrences as well as exposure to drugs or toxins that lead to degeneration of the disc. This brief overview establishes a necessary starting point for the understanding of these processes as well as a preview into potential therapeutic targets.

Original languageEnglish (US)
Title of host publicationIntervertebral Disc Degeneration
Subtitle of host publicationPrevalence, Risk Factors and Treatments
PublisherNova Science Publishers, Inc.
Number of pages16
ISBN (Electronic)9781634858571
ISBN (Print)9781634858298
StatePublished - Jan 1 2016

ASJC Scopus subject areas

  • Medicine(all)


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