The OPTN Deceased Donor Potential Study: Implications for Policy and Practice

D. K. Klassen; L. B. Edwards; D. E. Stewart; A. K. Glazier; J. P. Orlowski; C. L. Berg; Karl J. McCleary; Gary B. Hirsch; L. Ebony Boulware; Gary King; Kevin A. Myer; Michael Reibel; John D. Rosendale; Khalid Saeed; Laura A. Siminoff; Samuel Soret; David A. Wagstaff; Kristina Wile; Joyce D.K. Essien; Betty C. Crandall; Danielle L. Cornell; David G. Jacobs; David W. Bosch; David H. Howard; Dorothy L. Faulkner; George F. Bergstrom; Gerald Rushton; Glen Franklin; Harry E. Wilkins; Hazhir Rahmandad; Howard M. Nathan; J. Elizabeth Tuttle-Newhall; James J. Wynn; Janice Whaley; Jennie P. Perryman; Jesse Schold; John Belcher; Julie A. Mayglothing; Karen Garcia; Kevin J. O'Conner; Laurie J. Kyckholm; Linda Ohler; Lori E. Markham; M. Anjali Sastry; Marcella Farinelli Fierro; Maria DeLauro; Mary Kelleher-Crabtree; Maryl R. Johnson; Meg M. Rogers; Nikolaos T. Pyrsopoulos; P. J. Geraghty; Paul K. Halverson; Renee Bennett; Richard D. Hasz; Robert S.D. Higgins; Stuart J. Youngner; Suzanne Lane Conrad; Thomas Mone; Thomas A. Nakagawa; Thomas P. Bleck; Timothy L. Pruett; Richard Durbin; Christopher J. McLaughlin; Teresa M. Belgay; Brian Shepard

doi:10.1111/ajt.13731

The OPTN Deceased Donor Potential Study: Implications for Policy and Practice

D. K. Klassen, L. B. Edwards, D. E. Stewart, A. K. Glazier, J. P. Orlowski, C. L. Berg, Karl J. McCleary, Gary B. Hirsch, L. Ebony Boulware, Gary King, Kevin A. Myer, Michael Reibel, John D. Rosendale, Khalid Saeed, Laura A. Siminoff, Samuel Soret, David A. Wagstaff, Kristina Wile, Joyce D.K. Essien, Betty C. CrandallDanielle L. Cornell, David G. Jacobs, David W. Bosch, David H. Howard, Dorothy L. Faulkner, George F. Bergstrom, Gerald Rushton, Glen Franklin, Harry E. Wilkins, Hazhir Rahmandad, Howard M. Nathan, J. Elizabeth Tuttle-Newhall, James J. Wynn, Janice Whaley, Jennie P. Perryman, Jesse Schold, John Belcher, Julie A. Mayglothing, Karen Garcia, Kevin J. O'Conner, Laurie J. Kyckholm, Linda Ohler, Lori E. Markham, M. Anjali Sastry, Marcella Farinelli Fierro, Maria DeLauro, Mary Kelleher-Crabtree, Maryl R. Johnson, Meg M. Rogers, Nikolaos T. Pyrsopoulos, P. J. Geraghty, Paul K. Halverson, Renee Bennett, Richard D. Hasz, Robert S.D. Higgins, Stuart J. Youngner, Suzanne Lane Conrad, Thomas Mone, Thomas A. Nakagawa, Thomas P. Bleck, Timothy L. Pruett, Richard Durbin, Christopher J. McLaughlin, Teresa M. Belgay, Brian Shepard

School of Medicine

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

The Organ Procurement and Transplantation Network (OPTN) Deceased Donor Potential Study, funded by the Health Resources and Services Administration, characterized the current pool of potential deceased donors and estimated changes through 2020. The goal was to inform policy development and suggest practice changes designed to increase the number of donors and organ transplants. Donor estimates used filtering methodologies applied to datasets from the OPTN, the National Center for Health Statistics, and the Agency for Healthcare Research and Quality and used these estimates with the number of actual donors to estimate the potential donor pool through 2020. Projected growth of the donor pool was 0.5% per year through 2020. Potential donor estimates suggested unrealized donor potential across all demographic groups, with the most significant unrealized potential (70%) in the 50–75-year-old age group and potential Donation after Circulatory Death (DCD) donors. Actual transplants that may be realized from potential donors in these categories are constrained by confounding medical comorbidities not identified in administrative databases and by limiting utilization practices for organs from DCD donors. Policy, regulatory, and practice changes encouraging organ procurement and transplantation of a broader population of potential donors may be required to increase transplant numbers in the United States.

Original language	English (US)
Pages (from-to)	1707-1714
Number of pages	8
Journal	American Journal of Transplantation
Volume	16
Issue number	6
DOIs	https://doi.org/10.1111/ajt.13731
State	Published - 2016

ASJC Scopus subject areas

Immunology and Allergy
Transplantation
Pharmacology (medical)

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10.1111/ajt.13731

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Klassen, D. K., Edwards, L. B., Stewart, D. E., Glazier, A. K., Orlowski, J. P., Berg, C. L., McCleary, K. J., Hirsch, G. B., Boulware, L. E., King, G., Myer, K. A., Reibel, M., Rosendale, J. D., Saeed, K., Siminoff, L. A., Soret, S., Wagstaff, D. A., Wile, K., Essien, J. D. K., ... Shepard, B. (2016). The OPTN Deceased Donor Potential Study: Implications for Policy and Practice. American Journal of Transplantation, 16(6), 1707-1714. https://doi.org/10.1111/ajt.13731

Klassen, DK, Edwards, LB, Stewart, DE, Glazier, AK, Orlowski, JP, Berg, CL, McCleary, KJ, Hirsch, GB, Boulware, LE, King, G, Myer, KA, Reibel, M, Rosendale, JD, Saeed, K, Siminoff, LA, Soret, S, Wagstaff, DA, Wile, K, Essien, JDK, Crandall, BC, Cornell, DL, Jacobs, DG, Bosch, DW, Howard, DH, Faulkner, DL, Bergstrom, GF, Rushton, G, Franklin, G, Wilkins, HE, Rahmandad, H, Nathan, HM, Tuttle-Newhall, JE, Wynn, JJ, Whaley, J, Perryman, JP, Schold, J, Belcher, J, Mayglothing, JA, Garcia, K, O'Conner, KJ, Kyckholm, LJ, Ohler, L, Markham, LE, Sastry, MA, Farinelli Fierro, M, DeLauro, M, Kelleher-Crabtree, M, Johnson, MR, Rogers, MM, Pyrsopoulos, NT, Geraghty, PJ, Halverson, PK, Bennett, R, Hasz, RD, Higgins, RSD, Youngner, SJ, Conrad, SL, Mone, T, Nakagawa, TA, Bleck, TP, Pruett, TL, Durbin, R, McLaughlin, CJ, Belgay, TM & Shepard, B 2016, 'The OPTN Deceased Donor Potential Study: Implications for Policy and Practice', American Journal of Transplantation, vol. 16, no. 6, pp. 1707-1714. https://doi.org/10.1111/ajt.13731

@article{1cde4a3fc7b44901b821bd907e67c1d0,

title = "The OPTN Deceased Donor Potential Study: Implications for Policy and Practice",

abstract = "The Organ Procurement and Transplantation Network (OPTN) Deceased Donor Potential Study, funded by the Health Resources and Services Administration, characterized the current pool of potential deceased donors and estimated changes through 2020. The goal was to inform policy development and suggest practice changes designed to increase the number of donors and organ transplants. Donor estimates used filtering methodologies applied to datasets from the OPTN, the National Center for Health Statistics, and the Agency for Healthcare Research and Quality and used these estimates with the number of actual donors to estimate the potential donor pool through 2020. Projected growth of the donor pool was 0.5% per year through 2020. Potential donor estimates suggested unrealized donor potential across all demographic groups, with the most significant unrealized potential (70%) in the 50–75-year-old age group and potential Donation after Circulatory Death (DCD) donors. Actual transplants that may be realized from potential donors in these categories are constrained by confounding medical comorbidities not identified in administrative databases and by limiting utilization practices for organs from DCD donors. Policy, regulatory, and practice changes encouraging organ procurement and transplantation of a broader population of potential donors may be required to increase transplant numbers in the United States.",

author = "Klassen, {D. K.} and Edwards, {L. B.} and Stewart, {D. E.} and Glazier, {A. K.} and Orlowski, {J. P.} and Berg, {C. L.} and McCleary, {Karl J.} and Hirsch, {Gary B.} and Boulware, {L. Ebony} and Gary King and Myer, {Kevin A.} and Michael Reibel and Rosendale, {John D.} and Khalid Saeed and Siminoff, {Laura A.} and Samuel Soret and Wagstaff, {David A.} and Kristina Wile and Essien, {Joyce D.K.} and Crandall, {Betty C.} and Cornell, {Danielle L.} and Jacobs, {David G.} and Bosch, {David W.} and Howard, {David H.} and Faulkner, {Dorothy L.} and Bergstrom, {George F.} and Gerald Rushton and Glen Franklin and Wilkins, {Harry E.} and Hazhir Rahmandad and Nathan, {Howard M.} and Tuttle-Newhall, {J. Elizabeth} and Wynn, {James J.} and Janice Whaley and Perryman, {Jennie P.} and Jesse Schold and John Belcher and Mayglothing, {Julie A.} and Karen Garcia and O'Conner, {Kevin J.} and Kyckholm, {Laurie J.} and Linda Ohler and Markham, {Lori E.} and Sastry, {M. Anjali} and {Farinelli Fierro}, Marcella and Maria DeLauro and Mary Kelleher-Crabtree and Johnson, {Maryl R.} and Rogers, {Meg M.} and Pyrsopoulos, {Nikolaos T.} and Geraghty, {P. J.} and Halverson, {Paul K.} and Renee Bennett and Hasz, {Richard D.} and Higgins, {Robert S.D.} and Youngner, {Stuart J.} and Conrad, {Suzanne Lane} and Thomas Mone and Nakagawa, {Thomas A.} and Bleck, {Thomas P.} and Pruett, {Timothy L.} and Richard Durbin and McLaughlin, {Christopher J.} and Belgay, {Teresa M.} and Brian Shepard",

year = "2016",

doi = "10.1111/ajt.13731",

language = "English (US)",

volume = "16",

pages = "1707--1714",

journal = "American Journal of Transplantation",

issn = "1600-6135",

publisher = "Wiley-Blackwell",

number = "6",

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T1 - The OPTN Deceased Donor Potential Study

T2 - Implications for Policy and Practice

AU - Klassen, D. K.

AU - Edwards, L. B.

AU - Stewart, D. E.

AU - Glazier, A. K.

AU - Orlowski, J. P.

AU - Berg, C. L.

AU - McCleary, Karl J.

AU - Hirsch, Gary B.

AU - Boulware, L. Ebony

AU - King, Gary

AU - Myer, Kevin A.

AU - Reibel, Michael

AU - Rosendale, John D.

AU - Saeed, Khalid

AU - Siminoff, Laura A.

AU - Soret, Samuel

AU - Wagstaff, David A.

AU - Wile, Kristina

AU - Essien, Joyce D.K.

AU - Crandall, Betty C.

AU - Cornell, Danielle L.

AU - Jacobs, David G.

AU - Bosch, David W.

AU - Howard, David H.

AU - Faulkner, Dorothy L.

AU - Bergstrom, George F.

AU - Rushton, Gerald

AU - Franklin, Glen

AU - Wilkins, Harry E.

AU - Rahmandad, Hazhir

AU - Nathan, Howard M.

AU - Tuttle-Newhall, J. Elizabeth

AU - Wynn, James J.

AU - Whaley, Janice

AU - Perryman, Jennie P.

AU - Schold, Jesse

AU - Belcher, John

AU - Mayglothing, Julie A.

AU - Garcia, Karen

AU - O'Conner, Kevin J.

AU - Kyckholm, Laurie J.

AU - Ohler, Linda

AU - Markham, Lori E.

AU - Sastry, M. Anjali

AU - Farinelli Fierro, Marcella

AU - DeLauro, Maria

AU - Kelleher-Crabtree, Mary

AU - Johnson, Maryl R.

AU - Rogers, Meg M.

AU - Pyrsopoulos, Nikolaos T.

AU - Geraghty, P. J.

AU - Halverson, Paul K.

AU - Bennett, Renee

AU - Hasz, Richard D.

AU - Higgins, Robert S.D.

AU - Youngner, Stuart J.

AU - Conrad, Suzanne Lane

AU - Mone, Thomas

AU - Nakagawa, Thomas A.

AU - Bleck, Thomas P.

AU - Pruett, Timothy L.

AU - Durbin, Richard

AU - McLaughlin, Christopher J.

AU - Belgay, Teresa M.

AU - Shepard, Brian

PY - 2016

Y1 - 2016

N2 - The Organ Procurement and Transplantation Network (OPTN) Deceased Donor Potential Study, funded by the Health Resources and Services Administration, characterized the current pool of potential deceased donors and estimated changes through 2020. The goal was to inform policy development and suggest practice changes designed to increase the number of donors and organ transplants. Donor estimates used filtering methodologies applied to datasets from the OPTN, the National Center for Health Statistics, and the Agency for Healthcare Research and Quality and used these estimates with the number of actual donors to estimate the potential donor pool through 2020. Projected growth of the donor pool was 0.5% per year through 2020. Potential donor estimates suggested unrealized donor potential across all demographic groups, with the most significant unrealized potential (70%) in the 50–75-year-old age group and potential Donation after Circulatory Death (DCD) donors. Actual transplants that may be realized from potential donors in these categories are constrained by confounding medical comorbidities not identified in administrative databases and by limiting utilization practices for organs from DCD donors. Policy, regulatory, and practice changes encouraging organ procurement and transplantation of a broader population of potential donors may be required to increase transplant numbers in the United States.

AB - The Organ Procurement and Transplantation Network (OPTN) Deceased Donor Potential Study, funded by the Health Resources and Services Administration, characterized the current pool of potential deceased donors and estimated changes through 2020. The goal was to inform policy development and suggest practice changes designed to increase the number of donors and organ transplants. Donor estimates used filtering methodologies applied to datasets from the OPTN, the National Center for Health Statistics, and the Agency for Healthcare Research and Quality and used these estimates with the number of actual donors to estimate the potential donor pool through 2020. Projected growth of the donor pool was 0.5% per year through 2020. Potential donor estimates suggested unrealized donor potential across all demographic groups, with the most significant unrealized potential (70%) in the 50–75-year-old age group and potential Donation after Circulatory Death (DCD) donors. Actual transplants that may be realized from potential donors in these categories are constrained by confounding medical comorbidities not identified in administrative databases and by limiting utilization practices for organs from DCD donors. Policy, regulatory, and practice changes encouraging organ procurement and transplantation of a broader population of potential donors may be required to increase transplant numbers in the United States.

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The OPTN Deceased Donor Potential Study: Implications for Policy and Practice

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