TY - JOUR
T1 - The ongoing evolution of proteomics in malignancy
AU - Dhamoon, Amit S.
AU - Kohn, Elise C.
AU - Azad, Nilofer S.
N1 - Funding Information:
This work was supported by the Intramural Research Program of the NCI, National Institutes of Health, Center for Cancer Research.
PY - 2007/9
Y1 - 2007/9
N2 - The complementary fields of genomics and proteomics offer insights into the molecular mechanisms of diseases. While genomics seeks to define our genetic substrate, proteomics explores the structure and function of proteins, which are the end effectors of our genes. Proteomics has been revolutionized in the past decade by the application of techniques such as protein arrays, two-dimensional gel electrophoresis, and mass spectrometry. These techniques have tremendous potential for biomarker development, target validation, diagnosis, prognosis, and optimization of treatment in medical care, especially in the field of clinical oncology. We will discuss innovations in proteomic technologies and highlight their prospective applications to patient care.
AB - The complementary fields of genomics and proteomics offer insights into the molecular mechanisms of diseases. While genomics seeks to define our genetic substrate, proteomics explores the structure and function of proteins, which are the end effectors of our genes. Proteomics has been revolutionized in the past decade by the application of techniques such as protein arrays, two-dimensional gel electrophoresis, and mass spectrometry. These techniques have tremendous potential for biomarker development, target validation, diagnosis, prognosis, and optimization of treatment in medical care, especially in the field of clinical oncology. We will discuss innovations in proteomic technologies and highlight their prospective applications to patient care.
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U2 - 10.1016/j.drudis.2007.07.015
DO - 10.1016/j.drudis.2007.07.015
M3 - Review article
C2 - 17826682
AN - SCOPUS:34548428689
SN - 1359-6446
VL - 12
SP - 700
EP - 708
JO - Drug Discovery Today
JF - Drug Discovery Today
IS - 17-18
ER -