@article{9be14483d0ba490eb2013cac82540336,
title = "The “oldest and coldest” shipped living donor kidneys transplanted through kidney paired donation",
abstract = "To date, thousands of living donor kidneys have been shipped through kidney paired donation (KPD). To expand on this growing segment of living donor transplantation, we evaluated the effect of advanced age donation (“oldest kidneys”) and prolonged cold ischemia time (“coldest kidneys”) on graft function and survival using the National Kidney Registry database from February 2008 to May 2018. Donors were stratified by age at time of donation (<65 or ≥65 years) and kidneys were stratified by cold ischemia time (<16 or ≥16 hours). We evaluated delayed graft function and death-censored graft failure (DCGF) for up to seven posttransplant years. Of the 2363 shipped living donor kidney transplants, 4.1% of donors were ≥65 years and 6.0% of transplanted kidneys had cold ischemia times ≥16 hours. Delayed graft function and DCGF occurred in 5.2% and 4.7% of cases. There were no significant associations between delayed graft function and donor age (P =.947) or cold ischemia (P =.532). Donor age and cold ischemia time were not predictive of delayed graft function (OR = 0.86,1.20; P =.8,.6) or DCGF (HR = 1.38,0.35, P =.5,.1). These findings may alleviate concerns surrounding the utilization of kidneys from older donors or those originating from distant transplant centers.",
keywords = "clinical research/practice, donors and donation, donors and donation: living, donors and donation: paired exchange, kidney transplantation/nephrology, organ procurement and allocation",
author = "Nima Nassiri and Lorna Kwan and Aswani Bolagani and Thomas, {Alvin G.} and Joseph Sinacore and Matthew Ronin and Matthew Cooper and Segev, {Dorry L.} and Cecka, {J. Michael} and Veale, {Jeffrey L.}",
note = "Funding Information: This work was supported in part by grants number R01DK096008 (PI: Segev) and K24DK101828 (PI: Segev) from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); T32HL007055 (supporting Mr. Thomas) from the National Heart Lung and Blood Institute; and a research grant from the National Kidney Registry (PI: Segev). The analyses described here are the responsibility of the authors alone and do not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. The data reported here have been supplied by the Hennepin Healthcare Research Institute (HHRI) as the contractor for the Scientific Registry of Transplant Recipients. The interpretation and reporting of these data are the responsibility of the author(s) and in no way should be seen as an official policy of or interpretation by the SRTR or the U.S. Government. Funding Information: The authors of this manuscript have conflicts of interest to disclose as described by the American Journal of Transplantation . DLS reports research funding from the National Kidney Registry and National Institutes of Health. JS and MR are paid, full‐time employees of the National Kidney Registry. The other authors of this manuscript have no conflicts of interest to disclose. Funding Information: This work was supported in part by grants number R01DK096008 (PI: Segev) and K24DK101828 (PI: Segev) from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); T32HL007055 (supporting Mr. Thomas) from the National Heart Lung and Blood Institute; and a research grant from the National Kidney Registry (PI: Segev). The analyses described here are the responsibility of the authors alone and do not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. The data reported here have been supplied by the Hennepin Healthcare Research Institute (HHRI) as the contractor for the Scientific Registry of Transplant Recipients. The interpretation and reporting of these data are the responsibility of the author(s) and in no way should be seen as an official policy of or interpretation by the SRTR or the U.S. Government. Publisher Copyright: {\textcopyright} 2019 The American Society of Transplantation and the American Society of Transplant Surgeons",
year = "2020",
month = jan,
day = "1",
doi = "10.1111/ajt.15527",
language = "English (US)",
volume = "20",
pages = "137--144",
journal = "American Journal of Transplantation",
issn = "1600-6135",
publisher = "Wiley-Blackwell",
number = "1",
}