TY - JOUR
T1 - The nucleus accumbens core and shell are critical for the expression, but not the consolidation, of Pavlovian conditioned approach
AU - Blaiss, Cory A.
AU - Janak, Patricia H.
N1 - Funding Information:
We would like to thank L.L. Sahuque, R. Van Bautista, and Dr. N. Chaudhri for technical assistance and many helpful discussions. This work was supported by funds from the State of California for Medical Research on Alcohol and Substance Abuse through the University of California at San Francisco and NIDA grant #F31 DA016881 to C.A.B.
PY - 2009/6/8
Y1 - 2009/6/8
N2 - The nucleus accumbens (NAc) is important for the ability of motivationally significant stimuli to guide behavior. To further delineate its role in appetitive Pavlovian conditioning, we tested the hypothesis that the NAc contributes to memory consolidation and expression for a goal-tracking version of Pavlovian conditioned approach (PCA) in rats. We found that neither post-training reversible inactivation with the GABA receptor agonists muscimol and baclofen nor inhibition of protein synthesis with anisomycin (ANI) in either the core or shell regions of the NAc had an effect on approach to a reward port in response to a reward-predictive cue (conditioned stimulus, CS+). In contrast, pre-test reversible inactivation of both the core and shell decreased conditioned responding during the CS+. Unlike inactivation of the core, however, reversible inactivation of the shell also produced an increase in responding during the CS- and the inter-trial interval. This suggests that the NAc is not involved in the consolidation of goal-tracking PCA, but that once the memory is formed, the core is required for expression of the CS-unconditioned stimulus (US) association and the shell is required to inhibit conditioned approach behavior at times when the CS+ is not presented.
AB - The nucleus accumbens (NAc) is important for the ability of motivationally significant stimuli to guide behavior. To further delineate its role in appetitive Pavlovian conditioning, we tested the hypothesis that the NAc contributes to memory consolidation and expression for a goal-tracking version of Pavlovian conditioned approach (PCA) in rats. We found that neither post-training reversible inactivation with the GABA receptor agonists muscimol and baclofen nor inhibition of protein synthesis with anisomycin (ANI) in either the core or shell regions of the NAc had an effect on approach to a reward port in response to a reward-predictive cue (conditioned stimulus, CS+). In contrast, pre-test reversible inactivation of both the core and shell decreased conditioned responding during the CS+. Unlike inactivation of the core, however, reversible inactivation of the shell also produced an increase in responding during the CS- and the inter-trial interval. This suggests that the NAc is not involved in the consolidation of goal-tracking PCA, but that once the memory is formed, the core is required for expression of the CS-unconditioned stimulus (US) association and the shell is required to inhibit conditioned approach behavior at times when the CS+ is not presented.
KW - Appetitive conditioning
KW - Learning
KW - Memory
KW - Nucleus accumbens core
KW - Nucleus accumbens shell
KW - Pavlovian conditioning
KW - Rat
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U2 - 10.1016/j.bbr.2008.12.024
DO - 10.1016/j.bbr.2008.12.024
M3 - Article
C2 - 19159648
AN - SCOPUS:62649097698
SN - 0166-4328
VL - 200
SP - 22
EP - 32
JO - Behavioural Brain Research
JF - Behavioural Brain Research
IS - 1
ER -