The Not-So-Soft Spot: Pathophysiology of the Bulging Fontanelle in Association with Roseola

Thomas Cristoforo; Nicole K. Le; Summer Rye-Buckingham; William B. Hudson; Leslie F. Carroll

doi:10.1097/PEC.0000000000001447

The Not-So-Soft Spot: Pathophysiology of the Bulging Fontanelle in Association with Roseola

Thomas Cristoforo, Nicole K. Le, Summer Rye-Buckingham, William B. Hudson, Leslie F. Carroll

All Children's Hospital

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Roseola infantum is a clinical syndrome characterized by high fever followed by the emergence of a rash. Case reports have documented an association between bulging fontanelles and roseola. We propose a novel mechanism for the development of intracranial hypertension caused by human herpesvirus 6-induced cytokine elevation leading to increased cerebrospinal fluid production.

Original language	English (US)
Pages (from-to)	E576-E578
Journal	Pediatric emergency care
Volume	36
Issue number	10
DOIs	https://doi.org/10.1097/PEC.0000000000001447
State	Published - Oct 1 2020

Keywords

CSF
HHV-6
cytokines
intracranial hypertension

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Emergency Medicine

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10.1097/PEC.0000000000001447

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abstract = "Roseola infantum is a clinical syndrome characterized by high fever followed by the emergence of a rash. Case reports have documented an association between bulging fontanelles and roseola. We propose a novel mechanism for the development of intracranial hypertension caused by human herpesvirus 6-induced cytokine elevation leading to increased cerebrospinal fluid production.",

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AU - Carroll, Leslie F.

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The Not-So-Soft Spot: Pathophysiology of the Bulging Fontanelle in Association with Roseola

Abstract

Keywords

ASJC Scopus subject areas

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