TY - JOUR
T1 - The neuropsychology of Huntington's disease
AU - Brandt, Jason
AU - Butters, Nelson
N1 - Funding Information:
This work has beens upporteidn part, by NIMH Grant MH38387 and NIH Grant NS16375, and funds from the Medical Research Service of the Veterans Administration.
PY - 1986
Y1 - 1986
N2 - The neuropsychological features of Huntington's disease (HD) include defects in concentration, egocentric spatial orientation, visuomotor integration, memory, manipulation of knowledge, and conceptual reasoning. The memory disorder of HD is prominent, but unlike that seen in amnesic syndromes. It is characterized by faulty retrieval strategies and possibly by deficits in skill learning. The qualitative features of the dementia of HD suggest that the caudate nucleus plays a major role in the spatial representation of information, the formation of plans of action, and the initiation of appropriate retrieval processes for searching working and long-term memory. As a group, individuals at risk for HD often display mild impairments similar to those affected, but these deficits have not yet been shown to be useful predictors of disease in individual cases.
AB - The neuropsychological features of Huntington's disease (HD) include defects in concentration, egocentric spatial orientation, visuomotor integration, memory, manipulation of knowledge, and conceptual reasoning. The memory disorder of HD is prominent, but unlike that seen in amnesic syndromes. It is characterized by faulty retrieval strategies and possibly by deficits in skill learning. The qualitative features of the dementia of HD suggest that the caudate nucleus plays a major role in the spatial representation of information, the formation of plans of action, and the initiation of appropriate retrieval processes for searching working and long-term memory. As a group, individuals at risk for HD often display mild impairments similar to those affected, but these deficits have not yet been shown to be useful predictors of disease in individual cases.
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U2 - 10.1016/0166-2236(86)90039-1
DO - 10.1016/0166-2236(86)90039-1
M3 - Review article
AN - SCOPUS:0022622002
SN - 0166-2236
VL - 9
SP - 118
EP - 120
JO - Trends in neurosciences
JF - Trends in neurosciences
IS - C
ER -