TY - JOUR
T1 - The National Cancer Database report on advanced-stage epithelial ovarian cancer
T2 - Impact of hospital surgical case volume on overall survival and surgical treatment paradigm
AU - Bristow, Robert E.
AU - Palis, Bryan E.
AU - Chi, Dennis S.
AU - Cliby, William A.
PY - 2010/9
Y1 - 2010/9
N2 - Objective: To examine the effect of hospital procedure volume and other prognostic variables on overall survival outcome and likelihood of receiving standard recommended care among patients with advanced-stage epithelial ovarian cancer. Methods: The National Cancer Data Base (NCDB) was searched for patients undergoing primary treatment for FIGO Stage IIIC/IV epithelial ovarian cancer from 1996 to 2005. The average annual surgical procedure volume was derived for each reporting hospital. Quartile ranking discriminated four groups of hospitals based on annual surgical volume: low (< 9), intermediate (9-20), high (21-35), and very high (> 35). Cox proportional hazards modeling was used to determine the impact on overall survival of hospital surgical volume adjusted for treatment, FIGO/AJCC stage, ethnicity, age, payer status, household income, and tumor grade. Binomial multivariate logistic regression modeling was used to assess differences in patient demographic, tumor, and treatment variables between high/very high volume hospitals and low/intermediate volume hospitals. Results: A total of 45,929 patients were identified. After adjusting for other factors, overall survival was significantly correlated with hospital case volume: very high (reference); high (HR 0.98, 95% CI = 0.92-1.04); intermediate (HR 1.08, 95% CI = 1.01-1.15); and low (HR 1.14, 95% CI = 1.07-1.22). Compared to low and intermediate volume hospitals, patients treated at very high and high-volume hospitals were less likely to receive neo-adjuvant chemotherapy (OR = 0.33, 95% CI = 1.18-1.50) or surgery alone (OR = 0.77, 95% CI = 0.73-0.82) instead of initial surgery and adjuvant chemotherapy. Conclusions: Hospital ovarian cancer surgical volume ≥ 21 cases/year is associated with a higher likelihood of patients with Stage IIIC/IV epithelial ovarian cancer receiving standard treatment (surgery followed by adjuvant chemotherapy). Even after adjusting for treatment paradigm and other factors, hospital volume ≥ 21 cases/year was significantly predictive of improved overall survival outcome.
AB - Objective: To examine the effect of hospital procedure volume and other prognostic variables on overall survival outcome and likelihood of receiving standard recommended care among patients with advanced-stage epithelial ovarian cancer. Methods: The National Cancer Data Base (NCDB) was searched for patients undergoing primary treatment for FIGO Stage IIIC/IV epithelial ovarian cancer from 1996 to 2005. The average annual surgical procedure volume was derived for each reporting hospital. Quartile ranking discriminated four groups of hospitals based on annual surgical volume: low (< 9), intermediate (9-20), high (21-35), and very high (> 35). Cox proportional hazards modeling was used to determine the impact on overall survival of hospital surgical volume adjusted for treatment, FIGO/AJCC stage, ethnicity, age, payer status, household income, and tumor grade. Binomial multivariate logistic regression modeling was used to assess differences in patient demographic, tumor, and treatment variables between high/very high volume hospitals and low/intermediate volume hospitals. Results: A total of 45,929 patients were identified. After adjusting for other factors, overall survival was significantly correlated with hospital case volume: very high (reference); high (HR 0.98, 95% CI = 0.92-1.04); intermediate (HR 1.08, 95% CI = 1.01-1.15); and low (HR 1.14, 95% CI = 1.07-1.22). Compared to low and intermediate volume hospitals, patients treated at very high and high-volume hospitals were less likely to receive neo-adjuvant chemotherapy (OR = 0.33, 95% CI = 1.18-1.50) or surgery alone (OR = 0.77, 95% CI = 0.73-0.82) instead of initial surgery and adjuvant chemotherapy. Conclusions: Hospital ovarian cancer surgical volume ≥ 21 cases/year is associated with a higher likelihood of patients with Stage IIIC/IV epithelial ovarian cancer receiving standard treatment (surgery followed by adjuvant chemotherapy). Even after adjusting for treatment paradigm and other factors, hospital volume ≥ 21 cases/year was significantly predictive of improved overall survival outcome.
KW - Ovarian cancer
KW - Surgical volume
KW - Survival
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U2 - 10.1016/j.ygyno.2010.05.025
DO - 10.1016/j.ygyno.2010.05.025
M3 - Article
C2 - 20573392
AN - SCOPUS:77955549719
SN - 0090-8258
VL - 118
SP - 262
EP - 267
JO - Gynecologic Oncology
JF - Gynecologic Oncology
IS - 3
ER -