The Mutagenicity and DNA-modifying Effect of Haloalkanes

Henry Brem; Aaron B. Stein; Herbert S. Rosenkranz

The Mutagenicity and DNA-modifying Effect of Haloalkanes

Henry Brem, Aaron B. Stein, Herbert S. Rosenkranz

Research output: Contribution to journal › Article › peer-review

Abstract

A series of haloalkanes, some of them widely used in industry and in the home, are shown to be mutagenic for Salmonella typhimurium and preferentially to inhibit the growth of DNA polymerase-deficient (pol A1-) Escherichia coli. It was found that the relative activities of the test substances differed when examined in these systems and that one of the agents was active in the pol A1- system only. In view of these results it is suggested that both assays be used in routine screening of environmental agents.

Original language	English (US)
Pages (from-to)	2576-2579
Number of pages	4
Journal	Cancer Research
Volume	34
Issue number	10
State	Published - Oct 1 1974
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

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N2 - A series of haloalkanes, some of them widely used in industry and in the home, are shown to be mutagenic for Salmonella typhimurium and preferentially to inhibit the growth of DNA polymerase-deficient (pol A1-) Escherichia coli. It was found that the relative activities of the test substances differed when examined in these systems and that one of the agents was active in the pol A1- system only. In view of these results it is suggested that both assays be used in routine screening of environmental agents.

AB - A series of haloalkanes, some of them widely used in industry and in the home, are shown to be mutagenic for Salmonella typhimurium and preferentially to inhibit the growth of DNA polymerase-deficient (pol A1-) Escherichia coli. It was found that the relative activities of the test substances differed when examined in these systems and that one of the agents was active in the pol A1- system only. In view of these results it is suggested that both assays be used in routine screening of environmental agents.

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The Mutagenicity and DNA-modifying Effect of Haloalkanes

Abstract

ASJC Scopus subject areas

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