The multistep nature of cancer

Research output: Contribution to journalReview articlepeer-review

1454 Scopus citations


Cancer is a distinct type of genetic disease in which not one, but several, mutations are required. Each mutation drives a wave of cellular multiplication associated with gradual increases in tumor size, disorganization and malignancy. Three to six such mutations appear to be required to complete this process.

Original languageEnglish (US)
Pages (from-to)138-141
Number of pages4
JournalTrends in Genetics
Issue number4
StatePublished - Apr 1993

ASJC Scopus subject areas

  • Genetics


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