The multistep nature of cancer

Bert Vogelstein; Kenneth W. Kinzler

doi:10.1016/0168-9525(93)90209-Z

The multistep nature of cancer

Bert Vogelstein, Kenneth W. Kinzler

Research output: Contribution to journal › Review article › peer-review

1454 Scopus citations

Abstract

Cancer is a distinct type of genetic disease in which not one, but several, mutations are required. Each mutation drives a wave of cellular multiplication associated with gradual increases in tumor size, disorganization and malignancy. Three to six such mutations appear to be required to complete this process.

Original language	English (US)
Pages (from-to)	138-141
Number of pages	4
Journal	Trends in Genetics
Volume	9
Issue number	4
DOIs	https://doi.org/10.1016/0168-9525(93)90209-Z
State	Published - Apr 1993

ASJC Scopus subject areas

Genetics

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10.1016/0168-9525(93)90209-Z

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title = "The multistep nature of cancer",

abstract = "Cancer is a distinct type of genetic disease in which not one, but several, mutations are required. Each mutation drives a wave of cellular multiplication associated with gradual increases in tumor size, disorganization and malignancy. Three to six such mutations appear to be required to complete this process.",

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The multistep nature of cancer

Abstract

ASJC Scopus subject areas

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