The molecular events in heavy chain class-switching.

P. Rothman, S. C. Li, F. W. Alt

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


Heavy chain class-switching is the process by which B lymphoid cells change the constant region of the immunoglobulin heavy chain they produce. Class-switching is most commonly accomplished by recombinationldeletion between switch recombination regions that lie upstream of each germline heavy chain constant region gene. Recent studies support a model that recombination to specific switch regions is directed by modulation of the accessibility of these regions to a common class-switch recombination system. T cell lymphokines seem to be able to alter the accessibility of different heavy chain constant region loci, and thereby direct the specificity of class-switch recombination in B cells.

Original languageEnglish (US)
Pages (from-to)65-77
Number of pages13
JournalSeminars in immunology
Issue number1
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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