The molecular basis of hypopituitarism

Christopher J. Romero, Suzana Nesi-França, Sally Radovick

Research output: Contribution to journalReview articlepeer-review

43 Scopus citations


Hypopituitarism is defined as the deficiency of one or more of the hormones secreted by the pituitary gland. Several developmental factors necessary for pituitary embryogenesis and hormone secretion have been described, and mutations of these genes in humans provide a molecular understanding of hypopituitarism. Genetic studies of affected patients and their families provide insights into possible mechanisms of abnormal pituitary development; however, mutations are rare. This review characterizes several of these developmental proteins and their role in the pathogenesis of hypopituitarism. Continuing research is required to better understand the complexities and interplay between these pituitary factors and to make improvements in genetic diagnosis that can lead to early detection and provide a future cure.

Original languageEnglish (US)
Pages (from-to)506-516
Number of pages11
JournalTrends in Endocrinology and Metabolism
Issue number10
StatePublished - Dec 2009
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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