The mitochondrial regulator PGC1α is induced by cGMP–PKG signaling and mediates the protective effects of phosphodiesterase 5 inhibition in heart failure

Guangshuo Zhu, Kazutaka Ueda, Masaki Hashimoto, Manling Zhang, Masayuki Sasaki, Taro Kariya, Hideyuki Sasaki, Nina Kaludercic, Dong ik Lee, Djahida Bedja, Matthew Gabrielson, Yuan Yuan, Nazareno Paolocci, Robert M. Blanton, Richard H. Karas, Michael E. Mendelsohn, Brian O’Rourke, David A. Kass, Eiki Takimoto

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Medicine and Dentistry

Pharmacology, Toxicology and Pharmaceutical Science

Biochemistry, Genetics and Molecular Biology