The mitochondrial genome in aging and senescence

Andrea Lauri, Giulio Pompilio, Maurizio C. Capogrossi

Research output: Contribution to journalReview articlepeer-review

Abstract

Aging is characterized by a progressive decline in organism functions due to the impairment of all organs. The deterioration of both proliferative tissues in liver, skin and the vascular system, as well as of largely post-mitotic organs, such as the heart and brain could be attributed at least in part to cell senescence.In this review we examine the role of mitochondrial dysfunction and mtDNA mutations in cell aging and senescence. Specifically, we address how p53 and telomerase reverse transcriptase (TERT) activity switch their roles from cytoprotective to detrimental and also examine the role of microRNAs in cell aging. The proposed role of Reactive Oxygen Species (ROS), both as mutating agents and as signalling molecules, underlying these processes is also described.

Original languageEnglish (US)
Pages (from-to)1-15
Number of pages15
JournalAgeing Research Reviews
Volume18
DOIs
StatePublished - Nov 2014
Externally publishedYes

Keywords

  • Aging
  • Mitochondria
  • Molecular mechanisms
  • MtDNA
  • ROS
  • Senescence

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Aging
  • Molecular Biology
  • Neurology

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