The mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism

Michelle Grace Acoba; Ebru S.Selen Alpergin; Santosh Renuse; Lucía Fernández-del-Río; Ya Wen Lu; Oleh Khalimonchuk; Catherine F. Clarke; Akhilesh Pandey; Michael J. Wolfgang; Steven M. Claypool

doi:10.1016/j.celrep.2021.108869

The mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism

Michelle Grace Acoba, Ebru S.Selen Alpergin, Santosh Renuse, Lucía Fernández-del-Río, Ya Wen Lu, Oleh Khalimonchuk, Catherine F. Clarke, Akhilesh Pandey, Michael J. Wolfgang, Steven M. Claypool

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Acoba et al. show that the amino acid transporter SFXN1 is a cargo of the TIM22 translocon that is important for maintaining complex III function and supports coenzyme Q, heme, and α-ketoglutarate metabolism.

Original language	English (US)
Article number	108869
Journal	Cell Reports
Volume	34
Issue number	11
DOIs	https://doi.org/10.1016/j.celrep.2021.108869
State	Published - Mar 16 2021

Keywords

Complex III
OXPHOS
SFXN1
TIM22 complex
amino acid
heme
mitochondria
mitochondrial carrier
serine
sideroflexin

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/j.celrep.2021.108869

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title = "The mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism",

abstract = "Acoba et al. show that the amino acid transporter SFXN1 is a cargo of the TIM22 translocon that is important for maintaining complex III function and supports coenzyme Q, heme, and α-ketoglutarate metabolism.",

keywords = "Complex III, OXPHOS, SFXN1, TIM22 complex, amino acid, heme, mitochondria, mitochondrial carrier, serine, sideroflexin",

author = "Acoba, {Michelle Grace} and Alpergin, {Ebru S.Selen} and Santosh Renuse and Luc{\'i}a Fern{\'a}ndez-del-R{\'i}o and Lu, {Ya Wen} and Oleh Khalimonchuk and Clarke, {Catherine F.} and Akhilesh Pandey and Wolfgang, {Michael J.} and Claypool, {Steven M.}",

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year = "2021",

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doi = "10.1016/j.celrep.2021.108869",

language = "English (US)",

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AU - Acoba, Michelle Grace

AU - Alpergin, Ebru S.Selen

AU - Renuse, Santosh

AU - Fernández-del-Río, Lucía

AU - Lu, Ya Wen

AU - Khalimonchuk, Oleh

AU - Clarke, Catherine F.

AU - Pandey, Akhilesh

AU - Wolfgang, Michael J.

AU - Claypool, Steven M.

PY - 2021/3/16

Y1 - 2021/3/16

N2 - Acoba et al. show that the amino acid transporter SFXN1 is a cargo of the TIM22 translocon that is important for maintaining complex III function and supports coenzyme Q, heme, and α-ketoglutarate metabolism.

AB - Acoba et al. show that the amino acid transporter SFXN1 is a cargo of the TIM22 translocon that is important for maintaining complex III function and supports coenzyme Q, heme, and α-ketoglutarate metabolism.

KW - Complex III

KW - OXPHOS

KW - SFXN1

KW - TIM22 complex

KW - amino acid

KW - heme

KW - mitochondria

KW - mitochondrial carrier

KW - serine

KW - sideroflexin

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U2 - 10.1016/j.celrep.2021.108869

DO - 10.1016/j.celrep.2021.108869

M3 - Article

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AN - SCOPUS:85102490178

SN - 2211-1247

VL - 34

JO - Cell Reports

JF - Cell Reports

IS - 11

M1 - 108869

ER -

The mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism

Abstract

Keywords

ASJC Scopus subject areas

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