Objective: To investigate the CpG methylation locus and frequency pattern on p16INK4a gene promoter in epidermis of p16INK4a methylated patients with psoriasis vulgaris. Methods: The DNA specimens were obtained from epidermal lesion of 50 plaque psoriatic patients. Methylation specific PCR and DNA sequencing were used to detect the frequency and locus of methylation in p16INK4a gene promoter region. Results: Approximately 50% CpG was methylated in p16INK4a methylated patients, methylation was found in specifical locus of p16INK4a gene promoter. Conclusion: The distinct methylation pattern is showed on the p16INK4a gene promoter region in patients with psoriasis.
|Original language||English (US)|
|Number of pages||3|
|Journal||Chinese Journal of Medical Genetics|
|State||Published - Dec 10 2007|
- CpG methylation
- p16 gene
ASJC Scopus subject areas