The mechanism of eukaryotic translation initiation: New insights and challenges

Alan G. Hinnebusch; Jon R. Lorsch

doi:10.1101/cshperspect.a011544

The mechanism of eukaryotic translation initiation: New insights and challenges

Alan G. Hinnebusch, Jon R. Lorsch

Research output: Contribution to journal › Article › peer-review

258 Scopus citations

Abstract

Translation initiation in eukaryotes is a highly regulated and complex stage of gene expression. It requires the action of at least 12 initiation factors, many of which are known to be the targets of regulatory pathways. Here we review our current understanding of the molecular mechanics of eukaryotic translation initiation, focusing on recent breakthroughs fromin vitro and in vivo studies. We also identify important unanswered questions that will require new ideas and techniques to solve.

Original language	English (US)
Journal	Cold Spring Harbor Perspectives in Biology
Volume	4
Issue number	10
DOIs	https://doi.org/10.1101/cshperspect.a011544
State	Published - Oct 2012
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1101/cshperspect.a011544

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abstract = "Translation initiation in eukaryotes is a highly regulated and complex stage of gene expression. It requires the action of at least 12 initiation factors, many of which are known to be the targets of regulatory pathways. Here we review our current understanding of the molecular mechanics of eukaryotic translation initiation, focusing on recent breakthroughs fromin vitro and in vivo studies. We also identify important unanswered questions that will require new ideas and techniques to solve.",

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The mechanism of eukaryotic translation initiation: New insights and challenges

Abstract

ASJC Scopus subject areas

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