The matrix metalloproteinases and CNS plasticity: An overview

E. A. Milward; C. Fitzsimmons; A. Szklarczyk; K. Conant

doi:10.1016/j.jneuroim.2007.04.010

The matrix metalloproteinases and CNS plasticity: An overview

E. A. Milward, C. Fitzsimmons, A. Szklarczyk, K. Conant

Research output: Contribution to journal › Review article › peer-review

49 Scopus citations

Abstract

The matrix metalloproteinases (MMPs) are expressed in response to pro-inflammatory stimuli and other triggers. The MMPs cleave numerous substrates including extracellular matrix components, cytokines and growth factors. In the CNS, while most studied in the context of disease, the many physiological functions of the MMPs are now becoming appreciated. This review provides an overview of the growing body of evidence for physiological roles of MMPs both in CNS development and in CNS plasticity in normal brain functioning, including learning and memory, as well as in CNS repair and reorganization as part of the neuroimmune response to injury.

Original language	English (US)
Pages (from-to)	9-19
Number of pages	11
Journal	Journal of Neuroimmunology
Volume	187
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2007.04.010
State	Published - Jul 2007
Externally published	Yes

Keywords

CNS plasticity
Cognition
Development
Injury
Matrix metalloproteinases
TIMPs

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

Access to Document

10.1016/j.jneuroim.2007.04.010

Cite this

@article{7b3903ab6ed640dbabf1c73b8cf67775,

title = "The matrix metalloproteinases and CNS plasticity: An overview",

abstract = "The matrix metalloproteinases (MMPs) are expressed in response to pro-inflammatory stimuli and other triggers. The MMPs cleave numerous substrates including extracellular matrix components, cytokines and growth factors. In the CNS, while most studied in the context of disease, the many physiological functions of the MMPs are now becoming appreciated. This review provides an overview of the growing body of evidence for physiological roles of MMPs both in CNS development and in CNS plasticity in normal brain functioning, including learning and memory, as well as in CNS repair and reorganization as part of the neuroimmune response to injury.",

keywords = "CNS plasticity, Cognition, Development, Injury, Matrix metalloproteinases, TIMPs",

author = "Milward, {E. A.} and C. Fitzsimmons and A. Szklarczyk and K. Conant",

note = "Funding Information: We gratefully acknowledge the helpful contributions from Dr. Carlos Pardo and Wee Yong and funding from the National Multiple Sclerosis Society and the National Institutes of Health (NS052580).",

year = "2007",

month = jul,

doi = "10.1016/j.jneuroim.2007.04.010",

language = "English (US)",

volume = "187",

pages = "9--19",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier",

number = "1-2",

}

TY - JOUR

T1 - The matrix metalloproteinases and CNS plasticity

T2 - An overview

AU - Milward, E. A.

AU - Fitzsimmons, C.

AU - Szklarczyk, A.

AU - Conant, K.

N1 - Funding Information: We gratefully acknowledge the helpful contributions from Dr. Carlos Pardo and Wee Yong and funding from the National Multiple Sclerosis Society and the National Institutes of Health (NS052580).

PY - 2007/7

Y1 - 2007/7

N2 - The matrix metalloproteinases (MMPs) are expressed in response to pro-inflammatory stimuli and other triggers. The MMPs cleave numerous substrates including extracellular matrix components, cytokines and growth factors. In the CNS, while most studied in the context of disease, the many physiological functions of the MMPs are now becoming appreciated. This review provides an overview of the growing body of evidence for physiological roles of MMPs both in CNS development and in CNS plasticity in normal brain functioning, including learning and memory, as well as in CNS repair and reorganization as part of the neuroimmune response to injury.

AB - The matrix metalloproteinases (MMPs) are expressed in response to pro-inflammatory stimuli and other triggers. The MMPs cleave numerous substrates including extracellular matrix components, cytokines and growth factors. In the CNS, while most studied in the context of disease, the many physiological functions of the MMPs are now becoming appreciated. This review provides an overview of the growing body of evidence for physiological roles of MMPs both in CNS development and in CNS plasticity in normal brain functioning, including learning and memory, as well as in CNS repair and reorganization as part of the neuroimmune response to injury.

KW - CNS plasticity

KW - Cognition

KW - Development

KW - Injury

KW - Matrix metalloproteinases

KW - TIMPs

UR - http://www.scopus.com/inward/record.url?scp=34347256340&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34347256340&partnerID=8YFLogxK

U2 - 10.1016/j.jneuroim.2007.04.010

DO - 10.1016/j.jneuroim.2007.04.010

M3 - Review article

C2 - 17555826

AN - SCOPUS:34347256340

SN - 0165-5728

VL - 187

SP - 9

EP - 19

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

The matrix metalloproteinases and CNS plasticity: An overview

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this