TY - JOUR
T1 - The master regulators of allergic inflammation
T2 - Dendritic cells in Th2 sensitization
AU - Eisenbarth, Stephanie C.
AU - Piggott, Damani A.
AU - Bottomly, Kim
PY - 2003/12
Y1 - 2003/12
N2 - The development of Th2 responses to inhaled proteins represents a malfunction of the adaptive immune system in that protein antigens are not microbial in nature and should not elicit an adaptive immune reaction. This derailing of the immune system may result from false alarms generated by the innate immune system, resulting in unexpected dendritic cell (DC) maturation after exposure to allergens. Conditions in the local microenvironment during DC maturation may also result in the preferential induction of Th2 responses. Recent progress has been made in our understanding of the role of DCs in both Th2 sensitization to aeroallergens and the regulation of Th2 and Th1 immunity.
AB - The development of Th2 responses to inhaled proteins represents a malfunction of the adaptive immune system in that protein antigens are not microbial in nature and should not elicit an adaptive immune reaction. This derailing of the immune system may result from false alarms generated by the innate immune system, resulting in unexpected dendritic cell (DC) maturation after exposure to allergens. Conditions in the local microenvironment during DC maturation may also result in the preferential induction of Th2 responses. Recent progress has been made in our understanding of the role of DCs in both Th2 sensitization to aeroallergens and the regulation of Th2 and Th1 immunity.
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U2 - 10.1016/j.coi.2003.09.003
DO - 10.1016/j.coi.2003.09.003
M3 - Review article
C2 - 14630194
AN - SCOPUS:0242491041
SN - 0952-7915
VL - 15
SP - 620
EP - 626
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 6
ER -