The link between large artery aging and cerebral small vessel disease

Angelo Scuteri, Edward G. Lakatta

Research output: Chapter in Book/Report/Conference proceedingChapter


Heterogeneity of the arterial system: When we were students of medicine, we learned that the fundamental law of static fluid dynamics is a variant of Ohm’s law: where the determinants of blood pressure (P) are peripheral resistance (R) and cardiac output (Q). For decades we have based our conceptualization of blood pressure therapy and prevention of cardiovascular (CV) events in terms of peripheral resistance and cardiac output [1]. According to Ohm’s Law, arterial properties between the center (heart) and the periphery (tissue) are not taken into account. In other terms, central elastic arteries play only the passive role of conduit tubes, delivering the blood from the center to the periphery. The microcirculation, in contrast, i.e., the peripheral arterial district whose diameter is around 300 μm and characterized by high resistance, governs a steady blood flow [2].

Original languageEnglish (US)
Title of host publicationCerebral Small Vessel Disease
PublisherCambridge University Press
Number of pages7
ISBN (Electronic)9781139382694
ISBN (Print)9781107031661
StatePublished - Jan 1 2011
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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