The late phase of preconditioning and its natural clinical application - Gene therapy

Roberto Bolli, Qian Hong Li, Xian Liang Tang, Yiru Guo, Yu Ting Xuan, Gregg Rokosh, Buddhadeb Dawn

Research output: Contribution to journalReview articlepeer-review

57 Scopus citations


There is little doubt that the discovery of ischemic preconditioning (PC) has been one of the fundamental milestones in the field of ischemic biology in the past 20 years. The purpose of this article is to review the pathophysiology and molecular basis of the late phase of myocardial PC. The exploitation of late PC for the development of novel gene therapy strategies aimed at inducing a permanently preconditioned cardiac phenotype (prophylactic cardioprotection) will also be discussed. Deciphering the mechanism of late PC has not only conceptual interest but also a considerable therapeutic implications, since transfer of the genes that underlie late PC would be expected to replicate the salubrious effects of this response of the heart to stress.

Original languageEnglish (US)
Pages (from-to)189-199
Number of pages11
JournalHeart Failure Reviews
Issue number3-4
StatePublished - Dec 2007
Externally publishedYes


  • Cyclooxygenase-2
  • Late preconditioning
  • Nitric oxide synthase
  • Protection

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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