The kinetics of interferon induction by poly ICLC in humans

C. T. Bever; H. F. McFarland; D. E. McFarlin; H. B. Levy

The kinetics of interferon induction by poly ICLC in humans

C. T. Bever, H. F. McFarland, D. E. McFarlin, H. B. Levy

Research output: Contribution to journal › Article › peer-review

Abstract

A preliminary trial of the interferon (IFN) inducer polyriboinosinic acid-polyribocytidylic acid in poly-L-lysine and carboxymethylcellulose (poly ICLC) was conducted in patients with chronic progressive multiple sclerosis (MS). Because IFN induction in men greater than in women, the kinetics of IFN induction were studied. As no significant differences were found in the serum half-life of IFN, sex-linked differences in IFN clearance or degradation are not likely to be responsible for the differences noted. Because fever was the major limiting side effect in MS patients, the relationship of fever to IFN levels was assessed. Changes in temperature were not related to changes in IFN levels, suggesting that fever might be blocked without reducing IFN levels.

Original language	English (US)
Pages (from-to)	419-425
Number of pages	7
Journal	Journal of Interferon Research
Volume	8
Issue number	4
State	Published - 1988
Externally published	Yes

ASJC Scopus subject areas

Immunology
Virology

Cite this

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title = "The kinetics of interferon induction by poly ICLC in humans",

abstract = "A preliminary trial of the interferon (IFN) inducer polyriboinosinic acid-polyribocytidylic acid in poly-L-lysine and carboxymethylcellulose (poly ICLC) was conducted in patients with chronic progressive multiple sclerosis (MS). Because IFN induction in men greater than in women, the kinetics of IFN induction were studied. As no significant differences were found in the serum half-life of IFN, sex-linked differences in IFN clearance or degradation are not likely to be responsible for the differences noted. Because fever was the major limiting side effect in MS patients, the relationship of fever to IFN levels was assessed. Changes in temperature were not related to changes in IFN levels, suggesting that fever might be blocked without reducing IFN levels.",

author = "Bever, {C. T.} and McFarland, {H. F.} and McFarlin, {D. E.} and Levy, {H. B.}",

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AU - McFarlin, D. E.

AU - Levy, H. B.

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AB - A preliminary trial of the interferon (IFN) inducer polyriboinosinic acid-polyribocytidylic acid in poly-L-lysine and carboxymethylcellulose (poly ICLC) was conducted in patients with chronic progressive multiple sclerosis (MS). Because IFN induction in men greater than in women, the kinetics of IFN induction were studied. As no significant differences were found in the serum half-life of IFN, sex-linked differences in IFN clearance or degradation are not likely to be responsible for the differences noted. Because fever was the major limiting side effect in MS patients, the relationship of fever to IFN levels was assessed. Changes in temperature were not related to changes in IFN levels, suggesting that fever might be blocked without reducing IFN levels.

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JF - Journal of Interferon Research

IS - 4

ER -

The kinetics of interferon induction by poly ICLC in humans

Abstract

ASJC Scopus subject areas

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