The kinetics of interferon induction by poly ICLC in humans

C. T. Bever, H. F. McFarland, D. E. McFarlin, H. B. Levy

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


A preliminary trial of the interferon (IFN) inducer polyriboinosinic acid-polyribocytidylic acid in poly-L-lysine and carboxymethylcellulose (poly ICLC) was conducted in patients with chronic progressive multiple sclerosis (MS). Because IFN induction in men greater than in women, the kinetics of IFN induction were studied. As no significant differences were found in the serum half-life of IFN, sex-linked differences in IFN clearance or degradation are not likely to be responsible for the differences noted. Because fever was the major limiting side effect in MS patients, the relationship of fever to IFN levels was assessed. Changes in temperature were not related to changes in IFN levels, suggesting that fever might be blocked without reducing IFN levels.

Original languageEnglish (US)
Pages (from-to)419-425
Number of pages7
JournalJournal of Interferon Research
Issue number4
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Virology


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