The ketogenic diet in pharmacoresistant childhood epilepsy

Steven Parrish Winesett; Stacey Kordecki Bessone; Eric H.W. Kossoff

doi:10.1586/14737175.2015.1044982

The ketogenic diet in pharmacoresistant childhood epilepsy

Steven Parrish Winesett
, Stacey Kordecki Bessone
, Eric H.W. Kossoff

Research output: Contribution to journal › Review article › peer-review

39 Scopus citations

Abstract

Available pharmacologic treatments for seizures are limited in their efficacy. For a patient with seizures, pharmacologic treatment with available anticonvulsant medications leads to seizure control in <70% of patients. Surgical resection can lead to control in a select subset of patients but still leaves a significant number of patients with uncontrolled seizures. The ketogenic diet and related diets have proven to be useful in pharmacoresistant childhood epilepsy.

Original language	English (US)
Pages (from-to)	621-628
Number of pages	8
Journal	Expert review of neurotherapeutics
Volume	15
Issue number	6
DOIs	https://doi.org/10.1586/14737175.2015.1044982
State	Published - Jun 1 2015

Keywords

GLUT-1 deficiency
MCT diet
doose syndrome
epilepsy
infantile spasms
ketogenic
lennox-gastaut syndrome
low glycemic index diet
modified atkins diet
seizures

ASJC Scopus subject areas

General Neuroscience
Clinical Neurology
Pharmacology (medical)

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10.1586/14737175.2015.1044982

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title = "The ketogenic diet in pharmacoresistant childhood epilepsy",

abstract = "Available pharmacologic treatments for seizures are limited in their efficacy. For a patient with seizures, pharmacologic treatment with available anticonvulsant medications leads to seizure control in <70\% of patients. Surgical resection can lead to control in a select subset of patients but still leaves a significant number of patients with uncontrolled seizures. The ketogenic diet and related diets have proven to be useful in pharmacoresistant childhood epilepsy.",

keywords = "GLUT-1 deficiency, MCT diet, doose syndrome, epilepsy, infantile spasms, ketogenic, lennox-gastaut syndrome, low glycemic index diet, modified atkins diet, seizures",

author = "Winesett, \{Steven Parrish\} and Bessone, \{Stacey Kordecki\} and Kossoff, \{Eric H.W.\}",

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year = "2015",

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doi = "10.1586/14737175.2015.1044982",

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AU - Winesett, Steven Parrish

AU - Bessone, Stacey Kordecki

AU - Kossoff, Eric H.W.

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Y1 - 2015/6/1

N2 - Available pharmacologic treatments for seizures are limited in their efficacy. For a patient with seizures, pharmacologic treatment with available anticonvulsant medications leads to seizure control in <70% of patients. Surgical resection can lead to control in a select subset of patients but still leaves a significant number of patients with uncontrolled seizures. The ketogenic diet and related diets have proven to be useful in pharmacoresistant childhood epilepsy.

AB - Available pharmacologic treatments for seizures are limited in their efficacy. For a patient with seizures, pharmacologic treatment with available anticonvulsant medications leads to seizure control in <70% of patients. Surgical resection can lead to control in a select subset of patients but still leaves a significant number of patients with uncontrolled seizures. The ketogenic diet and related diets have proven to be useful in pharmacoresistant childhood epilepsy.

KW - GLUT-1 deficiency

KW - MCT diet

KW - doose syndrome

KW - epilepsy

KW - infantile spasms

KW - ketogenic

KW - lennox-gastaut syndrome

KW - low glycemic index diet

KW - modified atkins diet

KW - seizures

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DO - 10.1586/14737175.2015.1044982

M3 - Review article

C2 - 25994046

AN - SCOPUS:84930464372

SN - 1473-7175

VL - 15

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EP - 628

JO - Expert review of neurotherapeutics

JF - Expert review of neurotherapeutics

IS - 6

ER -

The ketogenic diet in pharmacoresistant childhood epilepsy

Abstract

Keywords

ASJC Scopus subject areas

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