The ketogenic diet for the treatment of epilepsy

M. Freeman, Epg Vininq Johns

Research output: Contribution to journalArticlepeer-review


The ketogenic diet is one of the oldest therapies for epilepsy. Now, as in the 1920's 15-30% of children with medicationrefractory seizures will have their seizures controlled with this carefully calculated, high fat-low protein-virtually no CHO diet. An additional 30-40% of children will have a greater than 50% reduction of seizures. For approximately 30% the diet is not sufficiently effective to continue. While eclipsed by anticonvulsants for several decades, the diet's recent resurgence for medication-refractory seizures in children has reawakened interest in its possible mechanisms of action. Recent studies of efficacy and directions for future research will be discussed.

Original languageEnglish (US)
Pages (from-to)A735
JournalFASEB Journal
Issue number3
StatePublished - 1996
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics


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