The ketogenic diet: Additional information from a crossover study

John M. Freeman

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


The purpose of this blinded, crossover study of the ketogenic diet in children with the Lennox-Gastaut syndrome was to confirm, by the addition of 60 g of glucose per day to negate the ketosis, that the effectiveness of the ketogenic diet was neither the result of a placebo effect nor due to parental expectations and commitment. We found that the additional glucose did not significantly alter the frequency of electroencephalography-assessed events, but did decrease the frequency of parent-reported "drop" seizures (P = .07). Fasting had substantial effects on both seizures and electroencephalography-assessed events. The diet remained effective in decreasing seizures of the Lennox-Gastaut syndrome at 12 days, 6 months, and 12 months. In conclusion, the ketogenic diet is effective in decreasing the drop seizures of the Lennox-Gastaut syndrome.

Original languageEnglish (US)
Pages (from-to)509-512
Number of pages4
JournalJournal of child neurology
Issue number4
StatePublished - Apr 16 2009


  • Crossover study
  • Epilepsy
  • Ketogenic diet

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology


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