Abstract
The purpose of this blinded, crossover study of the ketogenic diet in children with the Lennox-Gastaut syndrome was to confirm, by the addition of 60 g of glucose per day to negate the ketosis, that the effectiveness of the ketogenic diet was neither the result of a placebo effect nor due to parental expectations and commitment. We found that the additional glucose did not significantly alter the frequency of electroencephalography-assessed events, but did decrease the frequency of parent-reported "drop" seizures (P = .07). Fasting had substantial effects on both seizures and electroencephalography-assessed events. The diet remained effective in decreasing seizures of the Lennox-Gastaut syndrome at 12 days, 6 months, and 12 months. In conclusion, the ketogenic diet is effective in decreasing the drop seizures of the Lennox-Gastaut syndrome.
Original language | English (US) |
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Pages (from-to) | 509-512 |
Number of pages | 4 |
Journal | Journal of child neurology |
Volume | 24 |
Issue number | 4 |
DOIs | |
State | Published - Apr 16 2009 |
Keywords
- Crossover study
- Epilepsy
- Ketogenic diet
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Clinical Neurology