The intratumoral heterogeneity of cancer metabolism

Karim Nabi, Anne Le

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations


Heterogeneity is a hallmark of cancer.Clonal evolution theory and cancer stem cell theory explain tumor subpopulation growth.Intratumoral metabolism heterogeneity follows intratumoral genetics alterations.Epigenetics alterations lead to intratumoral metabolism heterogeneity.Intratumoral metabolic adaptation and heterogeneity are due to the intemperate conditions of the tumor microenvironment.Spatial and temporal heterogeneity provides survival advantages to tumors.Metabolic profile-targeted therapeutics can result in successful clinical outcomes.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Number of pages15
StatePublished - 2018
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019


  • Angiogenesis
  • Genetic and metabolic adaptation
  • Hypoxia
  • Intratumoral heterogeneity
  • Metabolism

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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