TY - JOUR
T1 - The International Society for Sexual Medicine's Process of Care for the Assessment and Management of Testosterone Deficiency in Adult Men
AU - Dean, John D.
AU - Mcmahon, Chris G.
AU - Guay, Andre T.
AU - Morgentaler, Abraham
AU - Althof, Stanley E.
AU - Becher, Edgardo F.
AU - Bivalacqua, Trinity J.
AU - Burnett, Arthur L.
AU - Buvat, Jacques
AU - El Meliegy, Amr
AU - Hellstrom, Wayne J.G.
AU - Jannini, Emmanuele A.
AU - Maggi, Mario
AU - Mccullough, Andrew
AU - Torres, Luiz Otavio
AU - Zitzmann, Michael
N1 - Funding Information:
The meeting was supported by an unrestricted grant from Repros Therapeutics Inc. However, ISSM required complete independence from industry during the development of the guideline and related resources. There were no industry representatives at the meeting and there was no attempt by industry to influence any part of the development or writing process at any time. The views or interests of the funding body, Repros Therapeutics Inc., have not influenced the final recommendations of the committee.
Publisher Copyright:
© 2015 International Society for Sexual Medicine.
PY - 2015/8/1
Y1 - 2015/8/1
N2 - Introduction: In 2014, the International Society for Sexual Medicine (ISSM) convened a panel of experts to develop an evidence-based process of care for the diagnosis and management of testosterone deficiency (TD) in adult men. The panel considered the definition, epidemiology, etiology, physiologic effects, diagnosis, assessment and treatment of TD. It also considered the treatment of TD in special populations and commented on contemporary controversies about testosterone replacement therapy, cardiovascular risk and prostate cancer. Aim: The aim was to develop clearly worded, practical, evidenced-based recommendations for the diagnosis and treatment of diagnosis and management of TD for clinicians without expertise in endocrinology, such as physicians in family medicine and general urology practice. Method: A comprehensive literature review was performed, followed by a structured, 3-day panel meeting and 6-month panel consultation process using electronic communication. The final guideline was compiled from reports by individual panel members on areas reflecting their special expertise, and then agreed by all through an iterative process. Results: This article contains the report of the ISSM TD Process of Care Committee. It offers a definition of TD and recommendations for assessment and treatment in different populations. Finally, best practice treatment recommendations are presented to guide clinicians, both familiar and unfamiliar with TD. Conclusion: Development of a process of care is an evolutionary process that continually reviews data and incorporates the best new research. We expect that ongoing research will lead to new insights into the pathophysiology of TD, as well as new, efficacious and safe treatments. We recommend that this process of care be reevaluated and updated by the ISSM in 4 years.
AB - Introduction: In 2014, the International Society for Sexual Medicine (ISSM) convened a panel of experts to develop an evidence-based process of care for the diagnosis and management of testosterone deficiency (TD) in adult men. The panel considered the definition, epidemiology, etiology, physiologic effects, diagnosis, assessment and treatment of TD. It also considered the treatment of TD in special populations and commented on contemporary controversies about testosterone replacement therapy, cardiovascular risk and prostate cancer. Aim: The aim was to develop clearly worded, practical, evidenced-based recommendations for the diagnosis and treatment of diagnosis and management of TD for clinicians without expertise in endocrinology, such as physicians in family medicine and general urology practice. Method: A comprehensive literature review was performed, followed by a structured, 3-day panel meeting and 6-month panel consultation process using electronic communication. The final guideline was compiled from reports by individual panel members on areas reflecting their special expertise, and then agreed by all through an iterative process. Results: This article contains the report of the ISSM TD Process of Care Committee. It offers a definition of TD and recommendations for assessment and treatment in different populations. Finally, best practice treatment recommendations are presented to guide clinicians, both familiar and unfamiliar with TD. Conclusion: Development of a process of care is an evolutionary process that continually reviews data and incorporates the best new research. We expect that ongoing research will lead to new insights into the pathophysiology of TD, as well as new, efficacious and safe treatments. We recommend that this process of care be reevaluated and updated by the ISSM in 4 years.
KW - Assessment of Hypogonadism
KW - Etiology of Hypogonadism
KW - Hypogonadism
KW - Testosterone Deficiency
KW - Treatment of Hypogonadism
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U2 - 10.1111/jsm.12952
DO - 10.1111/jsm.12952
M3 - Article
C2 - 26081680
AN - SCOPUS:84939534120
SN - 1743-6095
VL - 12
SP - 1660
EP - 1686
JO - Journal of Sexual Medicine
JF - Journal of Sexual Medicine
IS - 8
ER -