The insect microbiome modulates vector competence for arboviruses

Natapong Jupatanakul, Shuzhen Sim, George Dimopoulos

Research output: Contribution to journalReview articlepeer-review

89 Scopus citations


Diseases caused by arthropod-borne viruses (arboviruses), such as Dengue, West Nile, and Chikungunya, constitute a major global health burden and are increasing in incidence and geographic range. The natural microbiota of insect vectors influences various aspects of host biology, such as nutrition, reproduction, metabolism, and immunity, and recent studies have highlighted the ability of insect-associated bacteria to reduce vector competence for arboviruses and other pathogens. This reduction can occur through mechanisms, such as immune response activation, resource competition, or the production of anti-viral molecules. Studying the interactions between insect vectors and their microbiota is an important step toward developing alternative strategies for arbovirus transmission control.

Original languageEnglish (US)
Article number11
Pages (from-to)4294-4313
Number of pages20
Issue number11
StatePublished - Nov 11 2014


  • Aedes
  • Arbovirus
  • Culex
  • Innate immunity
  • Microbiota
  • Mosquito

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology


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