The innate and adaptive response to mosquito saliva and Plasmodium sporozoites in the skin

Christine S. Hopp; Photini Sinnis

doi:10.1111/nyas.12661

The innate and adaptive response to mosquito saliva and Plasmodium sporozoites in the skin

Christine S. Hopp, Photini Sinnis

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

A malaria infection begins when an infected mosquito takes a blood meal and inoculates parasites into the skin of its mammalian host. The parasite then has to exit the skin and escape the immune cells that protect the body from infection and alert the system to intruding pathogens. It has become apparent that this earliest stage of infection is amenable to vaccine interventions. Here, we discuss how the innate and adaptive host response to both mosquito saliva and the parasite may interfere with the infection, as well as possible mechanisms the parasite might use to circumvent the host defense.

Original language	English (US)
Pages (from-to)	37-43
Number of pages	7
Journal	Annals of the New York Academy of Sciences
Volume	1342
Issue number	1
DOIs	https://doi.org/10.1111/nyas.12661
State	Published - Apr 1 2015

Keywords

Dermal immune system
Human adaptive immunity
Human innate immunity
Malaria
Mosquito saliva
Rodent malaria model
Sporozoite

ASJC Scopus subject areas

Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
History and Philosophy of Science

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10.1111/nyas.12661

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abstract = "A malaria infection begins when an infected mosquito takes a blood meal and inoculates parasites into the skin of its mammalian host. The parasite then has to exit the skin and escape the immune cells that protect the body from infection and alert the system to intruding pathogens. It has become apparent that this earliest stage of infection is amenable to vaccine interventions. Here, we discuss how the innate and adaptive host response to both mosquito saliva and the parasite may interfere with the infection, as well as possible mechanisms the parasite might use to circumvent the host defense.",

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AB - A malaria infection begins when an infected mosquito takes a blood meal and inoculates parasites into the skin of its mammalian host. The parasite then has to exit the skin and escape the immune cells that protect the body from infection and alert the system to intruding pathogens. It has become apparent that this earliest stage of infection is amenable to vaccine interventions. Here, we discuss how the innate and adaptive host response to both mosquito saliva and the parasite may interfere with the infection, as well as possible mechanisms the parasite might use to circumvent the host defense.

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KW - Human innate immunity

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KW - Mosquito saliva

KW - Rodent malaria model

KW - Sporozoite

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The innate and adaptive response to mosquito saliva and Plasmodium sporozoites in the skin

Abstract

Keywords

ASJC Scopus subject areas

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