The initiation and early development of autoimmune diseases

Gordon L. Ada, Noel R. Rose

Research output: Contribution to journalShort surveypeer-review

20 Scopus citations


Our understanding of autoimmunity has changed considerably over the past years as a consequence of the demonstration that self-reactive B cells and T cells are not necessarily deleted from the immunological vocabulary. The critical event in initiating (or avoiding) autoimmune responses is presentation to T cells of the self-peptide-MHC antigen complex. Based on the premise that quantitative aspects are of paramount importance, we suggest that T-cell activity, MHC expression, and self-peptide binding determine the initiation of autoimmune responses.

Original languageEnglish (US)
Pages (from-to)3-9
Number of pages7
JournalClinical Immunology and Immunopathology
Issue number1
StatePublished - Apr 1988

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology


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