Abstract
We have shown that normal C57BL/6J mice are moderately resistant to infection with murine cytomegalovirus (MCMV) and that this resistance is impaired by prior infection with LP-BM5 MuLV, which causes a disease (MAIDS) similar to early HIV-induced disease. This study investigates macrophage function in MAIDS+ mice challenged with MCMV. MAIDS reduces the influx of cells into the peritoneal cavity seen in normal C57BL/6J mice 6 days after MCMV infection. The infiltrates contained cells that resembled activated macrophages, as they took up colloidal gold, expressed the macrophage marker Mac-1, had high levels of acid phosphatase activity, and were lymphocytostatic when co-cultured with activated T cells. MAIDS+ mice had a higher percentage of cells able to take up colloidal gold and higher acid phosphatase activity per cell. The cells were also more lymphocytostatic and produced higher levels of interleukin-1 and tumor necrosis factor-α on days 4 and 6 after MCMV infection. Hence, MAIDS enhances baseline and induced macrophage activity, but depresses infiltration into the site of inflammation.
Original language | English (US) |
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Pages (from-to) | 44-50 |
Number of pages | 7 |
Journal | Journal of Leukocyte Biology |
Volume | 60 |
Issue number | 1 |
DOIs | |
State | Published - Jul 1996 |
Externally published | Yes |
Keywords
- Inflammation
- Interleukin-1
- Tumor necrosis factor-α
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Cell Biology