The importance of surgical margins in primary malignancies of the liver

Kelly Lafaro, Miral Sadaria Grandhi, Joseph M. Herman, Timothy M. Pawlik

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations


Resection is an important treatment modality for hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). Anatomic resection is generally preferred for HCC. When anatomic resection is not feasible, prospective data have demonstrated an improved outcome among HCC patients who have a resection with wide versus narrow surgical margins. Similarly, among patients with ICC, R1 resection has been associated with worse outcomes. In addition, margin width may also impact risk of recurrence and survival. As such, provided adequate functional liver remnant remains, anatomic resection with wide margins is recommended for HCC and ICC.

Original languageEnglish (US)
Pages (from-to)296-303
Number of pages8
JournalJournal of Surgical Oncology
Issue number3
StatePublished - Mar 1 2016


  • hepatocellular carcinoma
  • intrahepatic cholangiocarcinoma
  • liver cancer
  • surgical margins

ASJC Scopus subject areas

  • Surgery
  • Oncology


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