The importance of circulating and disseminated tumor cells in pancreatic cancer

Alina Hasanain; Barbara Aldana Blanco; Jun Yu; Christopher L. Wolfgang

doi:10.1016/j.sopen.2019.08.002

The importance of circulating and disseminated tumor cells in pancreatic cancer

Alina Hasanain, Barbara Aldana Blanco, Jun Yu, Christopher L. Wolfgang

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Pancreatic cancer is a lethal disease in a large part due to the systemic nature at the time of diagnosis. In those patients who undergo a potentially curative resection of pancreatic cancer, the overwhelming majority will have systemic relapse. Circulating tumor cells are an important mediator of the development of metastases. Circulating tumor cells have been identified in patients with clinically localized resectable pancreatic cancer and exist as several phenotypes. Mesenchymal and stem cell–like phenotypes of circulating tumor cells predict early recurrence and worse survival. This review focuses on the current understanding of circulating tumor cells in pancreatic cancer and how this information can be used in developing more effective therapy in the future.

Original language	English (US)
Pages (from-to)	49-55
Number of pages	7
Journal	Surgery Open Science
Volume	1
Issue number	2
DOIs	https://doi.org/10.1016/j.sopen.2019.08.002
State	Published - Oct 2019

ASJC Scopus subject areas

Surgery

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10.1016/j.sopen.2019.08.002

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title = "The importance of circulating and disseminated tumor cells in pancreatic cancer",

abstract = "Pancreatic cancer is a lethal disease in a large part due to the systemic nature at the time of diagnosis. In those patients who undergo a potentially curative resection of pancreatic cancer, the overwhelming majority will have systemic relapse. Circulating tumor cells are an important mediator of the development of metastases. Circulating tumor cells have been identified in patients with clinically localized resectable pancreatic cancer and exist as several phenotypes. Mesenchymal and stem cell–like phenotypes of circulating tumor cells predict early recurrence and worse survival. This review focuses on the current understanding of circulating tumor cells in pancreatic cancer and how this information can be used in developing more effective therapy in the future.",

author = "Alina Hasanain and Blanco, {Barbara Aldana} and Jun Yu and Wolfgang, {Christopher L.}",

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year = "2019",

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doi = "10.1016/j.sopen.2019.08.002",

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AU - Blanco, Barbara Aldana

AU - Yu, Jun

AU - Wolfgang, Christopher L.

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Y1 - 2019/10

N2 - Pancreatic cancer is a lethal disease in a large part due to the systemic nature at the time of diagnosis. In those patients who undergo a potentially curative resection of pancreatic cancer, the overwhelming majority will have systemic relapse. Circulating tumor cells are an important mediator of the development of metastases. Circulating tumor cells have been identified in patients with clinically localized resectable pancreatic cancer and exist as several phenotypes. Mesenchymal and stem cell–like phenotypes of circulating tumor cells predict early recurrence and worse survival. This review focuses on the current understanding of circulating tumor cells in pancreatic cancer and how this information can be used in developing more effective therapy in the future.

AB - Pancreatic cancer is a lethal disease in a large part due to the systemic nature at the time of diagnosis. In those patients who undergo a potentially curative resection of pancreatic cancer, the overwhelming majority will have systemic relapse. Circulating tumor cells are an important mediator of the development of metastases. Circulating tumor cells have been identified in patients with clinically localized resectable pancreatic cancer and exist as several phenotypes. Mesenchymal and stem cell–like phenotypes of circulating tumor cells predict early recurrence and worse survival. This review focuses on the current understanding of circulating tumor cells in pancreatic cancer and how this information can be used in developing more effective therapy in the future.

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The importance of circulating and disseminated tumor cells in pancreatic cancer

Abstract

ASJC Scopus subject areas

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