The impact of Val108/158Met polymorphism of catechol-O-methyltransferase on brain oscillations during working memory

Mario Altamura; Brita Elvevåg; Terry E. Goldberg; Frederick W. Carver; Daniel R. Weinberger; Richard Coppola

doi:10.1016/j.neulet.2015.10.018

The impact of Val108/158Met polymorphism of catechol-O-methyltransferase on brain oscillations during working memory

Mario Altamura, Brita Elvevåg, Terry E. Goldberg, Frederick W. Carver, Daniel R. Weinberger, Richard Coppola

School of Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

This study investigated whether catechol- O-methyltransferase (COMT) Val/Met polymorphism was associated with variation in event-related desynchronization/synchronization (ERD/ERS) of responses during working memory (WM). 11 Val/Val and 11 Met/Met homozygous participants underwent magnetoencephalography (MEG) while performing a WM task. In contrast to small effects behaviourally, during the delay period Val/Val individuals showed lower ERS in the gamma band (Hz 30-50) in frontal regions, increased ERS in the alpha band (Hz 8-12) in the right frontal and parietal regions and increased ERD in the beta band (Hz 14-30) in the left fronto-temporal regions as compared with Met/Met homozygous individuals. During the response period Val/Val participants showed greater beta ERD in the prefrontal and parietotemporal regions. These results demonstrate that COMT genotype has a strong impact on brain responses (oscillatory activity) during WM performance likely a consequence of compensatory activity during the delay and response periods.

Original language	English (US)
Pages (from-to)	86-91
Number of pages	6
Journal	Neuroscience Letters
Volume	610
DOIs	https://doi.org/10.1016/j.neulet.2015.10.018
State	Published - Jan 1 2016

Keywords

Dopamine
Event-related desynchronization (ERD)
Event-related synchronization (ERS)
Frontal lobe
Genetics
Human memory

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/j.neulet.2015.10.018

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title = "The impact of Val108/158Met polymorphism of catechol-O-methyltransferase on brain oscillations during working memory",

abstract = "This study investigated whether catechol- O-methyltransferase (COMT) Val/Met polymorphism was associated with variation in event-related desynchronization/synchronization (ERD/ERS) of responses during working memory (WM). 11 Val/Val and 11 Met/Met homozygous participants underwent magnetoencephalography (MEG) while performing a WM task. In contrast to small effects behaviourally, during the delay period Val/Val individuals showed lower ERS in the gamma band (Hz 30-50) in frontal regions, increased ERS in the alpha band (Hz 8-12) in the right frontal and parietal regions and increased ERD in the beta band (Hz 14-30) in the left fronto-temporal regions as compared with Met/Met homozygous individuals. During the response period Val/Val participants showed greater beta ERD in the prefrontal and parietotemporal regions. These results demonstrate that COMT genotype has a strong impact on brain responses (oscillatory activity) during WM performance likely a consequence of compensatory activity during the delay and response periods.",

keywords = "Dopamine, Event-related desynchronization (ERD), Event-related synchronization (ERS), Frontal lobe, Genetics, Human memory",

author = "Mario Altamura and Brita Elvev{\aa}g and Goldberg, {Terry E.} and Carver, {Frederick W.} and Weinberger, {Daniel R.} and Richard Coppola",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Ireland Ltd.",

year = "2016",

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doi = "10.1016/j.neulet.2015.10.018",

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AU - Elvevåg, Brita

AU - Goldberg, Terry E.

AU - Carver, Frederick W.

AU - Weinberger, Daniel R.

AU - Coppola, Richard

PY - 2016/1/1

Y1 - 2016/1/1

N2 - This study investigated whether catechol- O-methyltransferase (COMT) Val/Met polymorphism was associated with variation in event-related desynchronization/synchronization (ERD/ERS) of responses during working memory (WM). 11 Val/Val and 11 Met/Met homozygous participants underwent magnetoencephalography (MEG) while performing a WM task. In contrast to small effects behaviourally, during the delay period Val/Val individuals showed lower ERS in the gamma band (Hz 30-50) in frontal regions, increased ERS in the alpha band (Hz 8-12) in the right frontal and parietal regions and increased ERD in the beta band (Hz 14-30) in the left fronto-temporal regions as compared with Met/Met homozygous individuals. During the response period Val/Val participants showed greater beta ERD in the prefrontal and parietotemporal regions. These results demonstrate that COMT genotype has a strong impact on brain responses (oscillatory activity) during WM performance likely a consequence of compensatory activity during the delay and response periods.

AB - This study investigated whether catechol- O-methyltransferase (COMT) Val/Met polymorphism was associated with variation in event-related desynchronization/synchronization (ERD/ERS) of responses during working memory (WM). 11 Val/Val and 11 Met/Met homozygous participants underwent magnetoencephalography (MEG) while performing a WM task. In contrast to small effects behaviourally, during the delay period Val/Val individuals showed lower ERS in the gamma band (Hz 30-50) in frontal regions, increased ERS in the alpha band (Hz 8-12) in the right frontal and parietal regions and increased ERD in the beta band (Hz 14-30) in the left fronto-temporal regions as compared with Met/Met homozygous individuals. During the response period Val/Val participants showed greater beta ERD in the prefrontal and parietotemporal regions. These results demonstrate that COMT genotype has a strong impact on brain responses (oscillatory activity) during WM performance likely a consequence of compensatory activity during the delay and response periods.

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KW - Event-related synchronization (ERS)

KW - Frontal lobe

KW - Genetics

KW - Human memory

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The impact of Val108/158Met polymorphism of catechol-O-methyltransferase on brain oscillations during working memory

Abstract

Keywords

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