TY - JOUR
T1 - The impact of secondhand smoke exposure on children with cystic fibrosis
T2 - A review
AU - Kopp, Benjamin T.
AU - Ortega-García, Juan Antonio
AU - Christy Sadreameli, S.
AU - Wellmerling, Jack
AU - Cormet-Boyaka, Estelle
AU - Thompson, Rohan
AU - McGrath-Morrow, Sharon
AU - Groner, Judith A.
N1 - Publisher Copyright:
© 2016 by the author; licensee MDPI, Basel, Switzerland.
PY - 2016/10
Y1 - 2016/10
N2 - Secondhand smoke exposure (SHSe) has multiple adverse effects on lung function and growth, nutrition, and immune function in children; it is increasingly being recognized as an important modifier of disease severity for children with chronic diseases such as cystic fibrosis (CF). This review examines what is known regarding the prevalence of SHSe in CF, with the majority of reviewed studies utilizing parental-reporting of SHSe without an objective biomarker of exposure. A wide range of SHSe is reported in children with CF, but under-reporting is common in studies involving both reported and measured SHSe. Additionally, the impact of SHSe on respiratory and nutritional health is discussed, with potential decreases in long-term lung function, linear growth, and weight gain noted in CF children with SHSe. Immunologic function in children with CF and SHSe remains unknown. The impact of SHSe on cystic fibrosis transmembrane conductance regulator (CFTR) function is also examined, as reduced CFTR function may be a pathophysiologic consequence of SHSe in CF and could modulate therapeutic interventions. Finally, potential interventions for ongoing SHSe are delineated along with recommended future areas of study.
AB - Secondhand smoke exposure (SHSe) has multiple adverse effects on lung function and growth, nutrition, and immune function in children; it is increasingly being recognized as an important modifier of disease severity for children with chronic diseases such as cystic fibrosis (CF). This review examines what is known regarding the prevalence of SHSe in CF, with the majority of reviewed studies utilizing parental-reporting of SHSe without an objective biomarker of exposure. A wide range of SHSe is reported in children with CF, but under-reporting is common in studies involving both reported and measured SHSe. Additionally, the impact of SHSe on respiratory and nutritional health is discussed, with potential decreases in long-term lung function, linear growth, and weight gain noted in CF children with SHSe. Immunologic function in children with CF and SHSe remains unknown. The impact of SHSe on cystic fibrosis transmembrane conductance regulator (CFTR) function is also examined, as reduced CFTR function may be a pathophysiologic consequence of SHSe in CF and could modulate therapeutic interventions. Finally, potential interventions for ongoing SHSe are delineated along with recommended future areas of study.
KW - Cystic fibrosis
KW - Pediatric
KW - Tobacco
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U2 - 10.3390/ijerph13101003
DO - 10.3390/ijerph13101003
M3 - Review article
C2 - 27754353
AN - SCOPUS:84991736236
SN - 1661-7827
VL - 13
JO - International journal of environmental research and public health
JF - International journal of environmental research and public health
IS - 10
M1 - 1003
ER -