The Impact of Moderate or High-Intensity Combined Exercise on Systemic Inflammation among Older Persons with and without HIV

Kristine M. Erlandson, Melissa P. Wilson, Samantha Mawhinney, Eric Rapaport, Jay Liu, Cara C. Wilson, Jeremy T. Rahkola, Edward N. Janoff, Todd T. Brown, Thomas B. Campbell, Catherine M. Jankowski

Research output: Contribution to journalArticlepeer-review


Background: We investigated whether higher-intensity exercise provided greater decrease in markers of inflammation, and whether responses differed by HIV serostatus. Methods: People with HIV (PWH; n = 32) and controls (n = 37) aged 50-75 years completed 12 weeks moderate-intensity exercise, then were randomized to moderate-or high-intensity exercise for 12 additional weeks (n = 27 and 29, respectively). Inflammation biomarkers were measured at 0, 12, 24 weeks. Mixed and multiple regression models were adjusted for baseline inflammation, age, and body mass index. Results: Baseline tumor necrosis factor-α (TNF-α), soluble TNF receptor 2 (sTNFR2), and soluble CD14 (sCD14) were significantly higher among PWH than controls (P <. 04). From week 0-12, changes in interleukin-6 (IL-6), TNF-α, and sTNFR1 were not significantly different by HIV serostatus. We found no significant interaction between HIV serostatus/exercise intensity on week 12-24 changes in IL-6, TNF-α, and sTNFR1. Among high-intensity exercisers, PWH and controls had significant increases in sCD14 (P ≤. 003), controls significant increases in IL-10 (P =. 01), and PWH nonsignificant decrease in highly sensitive C-reactive protein (P =. 07). Other markers were not significantly different by serostatus or intensity. Conclusions: Moderate and high-intensity exercise elicited similar effects on inflammation among PWH and controls, with additional beneficial effects seen among high-intensity exercisers. Increase in sCD14 and attenuated IL-10 increase (PWH only) merit further study. Clinical Trials Registration: NCT02404792.

Original languageEnglish (US)
Pages (from-to)1161-1170
Number of pages10
JournalJournal of Infectious Diseases
Issue number7
StatePublished - Apr 1 2021


  • exercise
  • inflammation
  • microbial translocation
  • monocyte function

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases


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