The impact of mitotic errors on cell proliferation and tumorigenesis

Michelle S. Levine; Andrew J. Holland

doi:10.1101/gad.314351.118

The impact of mitotic errors on cell proliferation and tumorigenesis

Michelle S. Levine, Andrew J. Holland

School of Medicine

Research output: Contribution to journal › Review article › peer-review

53 Scopus citations

Abstract

Mitosis is a delicate event that must be executed with high fidelity to ensure genomic stability. Recent work has provided insight into how mitotic errors shape cancer genomes by driving both numerical and structural alterations in chromosomes that contribute to tumor initiation and progression. Here, we review the sources of mitotic errors in human tumors and their effect on cell fitness and transformation. We discuss new findings that suggest that chromosome missegregation can produce a proinflammatory environment and impact tumor responsiveness to immunotherapy. Finally, we survey the vulnerabilities exposed by cell division errors and how they can be exploited therapeutically.

Original language	English (US)
Pages (from-to)	620-638
Number of pages	19
Journal	Genes and Development
Volume	32
Issue number	9-10
DOIs	https://doi.org/10.1101/gad.314351.118
State	Published - May 1 2018

Keywords

Aneuploidy
Chromosomal instability
Mitosis

ASJC Scopus subject areas

Genetics
Developmental Biology

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10.1101/gad.314351.118

Cite this

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title = "The impact of mitotic errors on cell proliferation and tumorigenesis",

abstract = "Mitosis is a delicate event that must be executed with high fidelity to ensure genomic stability. Recent work has provided insight into how mitotic errors shape cancer genomes by driving both numerical and structural alterations in chromosomes that contribute to tumor initiation and progression. Here, we review the sources of mitotic errors in human tumors and their effect on cell fitness and transformation. We discuss new findings that suggest that chromosome missegregation can produce a proinflammatory environment and impact tumor responsiveness to immunotherapy. Finally, we survey the vulnerabilities exposed by cell division errors and how they can be exploited therapeutically.",

keywords = "Aneuploidy, Chromosomal instability, Mitosis",

author = "Levine, {Michelle S.} and Holland, {Andrew J.}",

note = "Funding Information: We thank our laboratory members for helpful discussions and apologize to colleagues whose work could not be cited due to space limitations. Work in the Holland laboratory was supported by a R01 research grant from the National Institutes of Health (NIH; GM 114119), an American Cancer Society Scholar grant (129742-RSG-16-156-01-CCG), and a March of Dimes Research grant (1-FY17-698) to A.J.H., and a National Research Service Award F31 grant from the NIH (GM122288) to M.S.L. Publisher Copyright: {\textcopyright} 2018 Levine and Holland.",

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N2 - Mitosis is a delicate event that must be executed with high fidelity to ensure genomic stability. Recent work has provided insight into how mitotic errors shape cancer genomes by driving both numerical and structural alterations in chromosomes that contribute to tumor initiation and progression. Here, we review the sources of mitotic errors in human tumors and their effect on cell fitness and transformation. We discuss new findings that suggest that chromosome missegregation can produce a proinflammatory environment and impact tumor responsiveness to immunotherapy. Finally, we survey the vulnerabilities exposed by cell division errors and how they can be exploited therapeutically.

AB - Mitosis is a delicate event that must be executed with high fidelity to ensure genomic stability. Recent work has provided insight into how mitotic errors shape cancer genomes by driving both numerical and structural alterations in chromosomes that contribute to tumor initiation and progression. Here, we review the sources of mitotic errors in human tumors and their effect on cell fitness and transformation. We discuss new findings that suggest that chromosome missegregation can produce a proinflammatory environment and impact tumor responsiveness to immunotherapy. Finally, we survey the vulnerabilities exposed by cell division errors and how they can be exploited therapeutically.

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KW - Chromosomal instability

KW - Mitosis

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The impact of mitotic errors on cell proliferation and tumorigenesis

Abstract

Keywords

ASJC Scopus subject areas

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