The impact of L1 retrotransposons on the human genome

Haig H. Kazazian, John V. Moran

Research output: Contribution to journalReview articlepeer-review

372 Scopus citations


The 'master' human mobile element, the L1 retrotransposon, has come of age as a biological entity. Knowledge of how it retrotransposes in vivo, how its proteins act to retrotranspose other poly A elements and the extent of its role in shaping the human genome should emerge rapidly over the next few years. We review the impact of retrotransposons and how new insight is likely to lead to important practical applications for these intriguing mobile elements.

Original languageEnglish (US)
Pages (from-to)19-24
Number of pages6
JournalNature genetics
Issue number1
StatePublished - 1998
Externally publishedYes

ASJC Scopus subject areas

  • Genetics


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