TY - JOUR
T1 - The impact of functional constipation on quality of life of middleaged Black Americans
T2 - A prospective case-control study
AU - Friedenberg, Frank K.
AU - Dadabhai, Alia
AU - Palit, Amiya
AU - Sankineni, Abhinav
N1 - Funding Information:
Acknowledgments This study was funded, in part, by Takeda Pharmaceuticals America, Deerfield, IL. Additional funding was provided by the National Institute of Health (Grant 1K24DK083268).
PY - 2012/12
Y1 - 2012/12
N2 - Purpose To quantify the impact of constipation on health-related quality of life (HRQoL) in Black Americans. Methods Case-control design. Black subjects referred for colon cancer screening with a Bristol Stool Score of 3-5 for >75% of bowel movements served as controls. Frequencymatched functional constipation subjects had to fulfill Rome III criteria. Both groups completed demographic and health surveys. Short Form-36 assessed HRQoL. Results We recruited 102 constipated patients and 100 controls. The groups were well matched demographically. After adjustment for comorbidities, SF-36 scores for vitality, bodily pain, social functioning, and role-emotional were significantly lower in constipated patients. Unadjusted physical and mental component summary scores (PCS and MCS) were significantly higher in the control group (47.1 ± 10.6 vs. 43.3 ± 8.6; P = 0.005 and 50.6 ± 12.4 vs. 43.4 ± 11.8; P < 0.001, respectively). After adjustment for comorbidities, PCS differences were no longer significant (P = 0.54); however, MCS differences were significant (P = 0.004). Marginal mean scores for the MCS for controls and constipated subjects were 49.9 ± 1.2 and 43.6 ± 1.2, respectively. The presence of a comorbidity was independently associated with PCS (P < 0.001) and MCS (P = 0.026) results. Conclusions Functional constipation has a significant impact on HRQoL in middle-aged Black Americans, particularly in regard to mental well-being.
AB - Purpose To quantify the impact of constipation on health-related quality of life (HRQoL) in Black Americans. Methods Case-control design. Black subjects referred for colon cancer screening with a Bristol Stool Score of 3-5 for >75% of bowel movements served as controls. Frequencymatched functional constipation subjects had to fulfill Rome III criteria. Both groups completed demographic and health surveys. Short Form-36 assessed HRQoL. Results We recruited 102 constipated patients and 100 controls. The groups were well matched demographically. After adjustment for comorbidities, SF-36 scores for vitality, bodily pain, social functioning, and role-emotional were significantly lower in constipated patients. Unadjusted physical and mental component summary scores (PCS and MCS) were significantly higher in the control group (47.1 ± 10.6 vs. 43.3 ± 8.6; P = 0.005 and 50.6 ± 12.4 vs. 43.4 ± 11.8; P < 0.001, respectively). After adjustment for comorbidities, PCS differences were no longer significant (P = 0.54); however, MCS differences were significant (P = 0.004). Marginal mean scores for the MCS for controls and constipated subjects were 49.9 ± 1.2 and 43.6 ± 1.2, respectively. The presence of a comorbidity was independently associated with PCS (P < 0.001) and MCS (P = 0.026) results. Conclusions Functional constipation has a significant impact on HRQoL in middle-aged Black Americans, particularly in regard to mental well-being.
KW - Black American
KW - Constipation
KW - Quality of life
KW - SF-36
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U2 - 10.1007/s11136-011-0089-z
DO - 10.1007/s11136-011-0089-z
M3 - Review article
C2 - 22179971
AN - SCOPUS:84872334750
SN - 0962-9343
VL - 21
SP - 1713
EP - 1717
JO - Quality of Life Research
JF - Quality of Life Research
IS - 10
ER -