The impact of antimicrobial resistance on health and economic outcomes

Sara E. Cosgrove, Yehuda Carmeli

Research output: Contribution to journalReview articlepeer-review

432 Scopus citations


Despite an increasing prevalence of antimicrobial-resistant pathogens, the health and economic impact of colonization and infection with these organisms has not been fully elucidated. We explore how antimicrobial resistance can affect patient outcomes by enhancing virulence, causing a delay in the administration of appropriate therapy, and limiting available therapy. Next, we examine the different perspectives held by hospitals, third-party payers, patients, and society on the impact of resistance. Finally, we review methodological issues in designing and assessing studies that address the clinical outcomes for patients infected or colonized with resistant pathogens, including adjustment for important confounding variables, control group selection, and the quantification of economic outcomes.

Original languageEnglish (US)
Pages (from-to)1433-1437
Number of pages5
JournalClinical Infectious Diseases
Issue number11
StatePublished - Jun 1 2003

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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