The immunoglobulin E receptor: Expression and regulation

Edward R. Conner; Sarbjit S. Saini

doi:10.1007/s11882-005-0037-5

The immunoglobulin E receptor: Expression and regulation

Edward R. Conner, Sarbjit S. Saini

School of Medicine

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

The interaction of immunoglobulin E (IgE) and its receptors is critical for the manifestation of allergic disease. Currently, IgE receptors include the high-affinity FcεRI and the low-affinity FcεRII. FcεRI is a tetrameric or trimeric complex, and each has distinct expression patterns and unique functional consequences. In general, serum levels of IgE regulate FcεRI expression, and novel therapies that lower the concentration of IgE have provided insights into the contribution of this receptor in allergic disease. Newer therapies targeting FcεRI-signaling elements and the low-affinity IgE receptor, FcεRII (CD23), are being developed.

Original language	English (US)
Pages (from-to)	191-196
Number of pages	6
Journal	Current allergy and asthma reports
Volume	5
Issue number	3
DOIs	https://doi.org/10.1007/s11882-005-0037-5
State	Published - May 2005

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Pulmonary and Respiratory Medicine

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abstract = "The interaction of immunoglobulin E (IgE) and its receptors is critical for the manifestation of allergic disease. Currently, IgE receptors include the high-affinity FcεRI and the low-affinity FcεRII. FcεRI is a tetrameric or trimeric complex, and each has distinct expression patterns and unique functional consequences. In general, serum levels of IgE regulate FcεRI expression, and novel therapies that lower the concentration of IgE have provided insights into the contribution of this receptor in allergic disease. Newer therapies targeting FcεRI-signaling elements and the low-affinity IgE receptor, FcεRII (CD23), are being developed.",

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AB - The interaction of immunoglobulin E (IgE) and its receptors is critical for the manifestation of allergic disease. Currently, IgE receptors include the high-affinity FcεRI and the low-affinity FcεRII. FcεRI is a tetrameric or trimeric complex, and each has distinct expression patterns and unique functional consequences. In general, serum levels of IgE regulate FcεRI expression, and novel therapies that lower the concentration of IgE have provided insights into the contribution of this receptor in allergic disease. Newer therapies targeting FcεRI-signaling elements and the low-affinity IgE receptor, FcεRII (CD23), are being developed.

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The immunoglobulin E receptor: Expression and regulation

Abstract

ASJC Scopus subject areas

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