The identification and measurement of two new metabolites of naltrexone in human urine

E. J. Cone; C. W. Gorodetzky; W. D. Darwin; F. I. Carroll; G. A. Brine; C. D. Welch

The identification and measurement of two new metabolites of naltrexone in human urine

E. J. Cone, C. W. Gorodetzky, W. D. Darwin, F. I. Carroll, G. A. Brine, C. D. Welch

Research output: Contribution to journal › Article › peer-review

Abstract

Two metabolites of naltrexone were identified in human and rat urine following drug administration. The metabolites, 2-hydroxy-3-0-methylnaltrexone and 2-hydroxy-3-0-methyl-6β-naltrexol, were identified by comparison of their respective gas chromatographic retention times and methane chemical ionization spectral patterns with authentic standards. The standards were obtained by chemical synthesis from naltrexone.

Original language	English (US)
Pages (from-to)	413-433
Number of pages	21
Journal	Research communications in chemical pathology and pharmacology
Volume	20
Issue number	3
State	Published - 1978
Externally published	Yes

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
Pathology and Forensic Medicine
Toxicology
Pharmacology

Cite this

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title = "The identification and measurement of two new metabolites of naltrexone in human urine",

abstract = "Two metabolites of naltrexone were identified in human and rat urine following drug administration. The metabolites, 2-hydroxy-3-0-methylnaltrexone and 2-hydroxy-3-0-methyl-6β-naltrexol, were identified by comparison of their respective gas chromatographic retention times and methane chemical ionization spectral patterns with authentic standards. The standards were obtained by chemical synthesis from naltrexone.",

author = "Cone, {E. J.} and Gorodetzky, {C. W.} and Darwin, {W. D.} and Carroll, {F. I.} and Brine, {G. A.} and Welch, {C. D.}",

year = "1978",

language = "English (US)",

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pages = "413--433",

journal = "Research communications in chemical pathology and pharmacology",

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T1 - The identification and measurement of two new metabolites of naltrexone in human urine

AU - Cone, E. J.

AU - Gorodetzky, C. W.

AU - Darwin, W. D.

AU - Carroll, F. I.

AU - Brine, G. A.

AU - Welch, C. D.

PY - 1978

Y1 - 1978

N2 - Two metabolites of naltrexone were identified in human and rat urine following drug administration. The metabolites, 2-hydroxy-3-0-methylnaltrexone and 2-hydroxy-3-0-methyl-6β-naltrexol, were identified by comparison of their respective gas chromatographic retention times and methane chemical ionization spectral patterns with authentic standards. The standards were obtained by chemical synthesis from naltrexone.

AB - Two metabolites of naltrexone were identified in human and rat urine following drug administration. The metabolites, 2-hydroxy-3-0-methylnaltrexone and 2-hydroxy-3-0-methyl-6β-naltrexol, were identified by comparison of their respective gas chromatographic retention times and methane chemical ionization spectral patterns with authentic standards. The standards were obtained by chemical synthesis from naltrexone.

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M3 - Article

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AN - SCOPUS:0018142614

SN - 0034-5164

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IS - 3

ER -

The identification and measurement of two new metabolites of naltrexone in human urine

Abstract

ASJC Scopus subject areas

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