The identification and measurement of two new metabolites of naltrexone in human urine

E. J. Cone; C. W. Gorodetzky; W. D. Darwin; F. I. Carroll; G. A. Brine; C. D. Welch

The identification and measurement of two new metabolites of naltrexone in human urine

E. J. Cone, C. W. Gorodetzky, W. D. Darwin, F. I. Carroll, G. A. Brine, C. D. Welch

School of Medicine

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Two metabolites of naltrexone were identified in human and rat urine following drug administration. The metabolites, 2-hydroxy-3-0-methylnaltrexone and 2-hydroxy-3-0-methyl-6β-naltrexol, were identified by comparison of their respective gas chromatographic retention times and methane chemical ionization spectral patterns with authentic standards. The standards were obtained by chemical synthesis from naltrexone.

Original language	English (US)
Pages (from-to)	413-433
Number of pages	21
Journal	Research Communications in Chemical Pathology and Pharmacology
Volume	20
Issue number	3
State	Published - Dec 1 1978

ASJC Scopus subject areas

Pathology and Forensic Medicine
Toxicology
Pharmacology
Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

@article{059dcd5620714af9a3f4aff4a8c6ee76,

title = "The identification and measurement of two new metabolites of naltrexone in human urine",

abstract = "Two metabolites of naltrexone were identified in human and rat urine following drug administration. The metabolites, 2-hydroxy-3-0-methylnaltrexone and 2-hydroxy-3-0-methyl-6β-naltrexol, were identified by comparison of their respective gas chromatographic retention times and methane chemical ionization spectral patterns with authentic standards. The standards were obtained by chemical synthesis from naltrexone.",

author = "Cone, {E. J.} and Gorodetzky, {C. W.} and Darwin, {W. D.} and Carroll, {F. I.} and Brine, {G. A.} and Welch, {C. D.}",

year = "1978",

month = dec,

day = "1",

language = "English (US)",

volume = "20",

pages = "413--433",

journal = "Research Communications in Chemical Pathology and Pharmacology",

issn = "0034-5164",

number = "3",

}

TY - JOUR

T1 - The identification and measurement of two new metabolites of naltrexone in human urine

AU - Cone, E. J.

AU - Gorodetzky, C. W.

AU - Darwin, W. D.

AU - Carroll, F. I.

AU - Brine, G. A.

AU - Welch, C. D.

PY - 1978/12/1

Y1 - 1978/12/1

N2 - Two metabolites of naltrexone were identified in human and rat urine following drug administration. The metabolites, 2-hydroxy-3-0-methylnaltrexone and 2-hydroxy-3-0-methyl-6β-naltrexol, were identified by comparison of their respective gas chromatographic retention times and methane chemical ionization spectral patterns with authentic standards. The standards were obtained by chemical synthesis from naltrexone.

AB - Two metabolites of naltrexone were identified in human and rat urine following drug administration. The metabolites, 2-hydroxy-3-0-methylnaltrexone and 2-hydroxy-3-0-methyl-6β-naltrexol, were identified by comparison of their respective gas chromatographic retention times and methane chemical ionization spectral patterns with authentic standards. The standards were obtained by chemical synthesis from naltrexone.

UR - http://www.scopus.com/inward/record.url?scp=0018142614&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018142614&partnerID=8YFLogxK

M3 - Article

C2 - 674824

AN - SCOPUS:0018142614

SN - 0034-5164

VL - 20

SP - 413

EP - 433

JO - Research Communications in Chemical Pathology and Pharmacology

JF - Research Communications in Chemical Pathology and Pharmacology

IS - 3

ER -

The identification and measurement of two new metabolites of naltrexone in human urine

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this