TY - JOUR
T1 - The hypoxic tumor microenvironment
T2 - A driving force for breast cancer progression
AU - Semenza, Gregg L.
N1 - Funding Information:
G.L.S. is an American Cancer Society Research Professor and the C. Michael Armstrong Professor at the Johns Hopkins University School of Medicine. Cancer research in his lab is supported by the American Cancer Society (122437-RP-12-090-01-COUN) and the Department of Defense Breast Cancer Research Program (Impact Award W81XWH-12-1-0464).
Funding Information:
G.L.S. is an American Cancer Society Research Professor and the C. Michael Armstrong Professor at the Johns Hopkins University School of Medicine. Cancer research in his lab is supported by the American Cancer Society ( 122437-RP-12-090-01-COUN ) and the Department of Defense Breast Cancer Research Program (Impact Award W81XWH-12-1-0464 ).
Publisher Copyright:
© 2015 Elsevier B.V.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Intratumoral hypoxia is a common finding in breast cancer and is associated with a significantly increased risk of metastasis and patient mortality. Hypoxia-inducible factors activate the transcription of a large battery of genes encoding proteins that promote primary tumor vascularization and growth, stromal cell recruitment, extracellular matrix remodeling, premetastatic niche formation, cell motility, local tissue invasion, extravasation at sites of metastasis, and maintenance of the cancer stem cell phenotype that is required to generate secondary tumors. Recent preclinical studies suggest that the combination of cytotoxic chemotherapy with drugs that inhibit hypoxia-inducible factors may improve outcome for women with triple-negative breast cancer. This article is part of a Special Issue entitled: Tumor Microenvironment Regulation of Cancer Cell Survival, Metastasis, Inflammation, and Immune Surveillance edited by Peter Ruvolo and Gregg L. Semenza.
AB - Intratumoral hypoxia is a common finding in breast cancer and is associated with a significantly increased risk of metastasis and patient mortality. Hypoxia-inducible factors activate the transcription of a large battery of genes encoding proteins that promote primary tumor vascularization and growth, stromal cell recruitment, extracellular matrix remodeling, premetastatic niche formation, cell motility, local tissue invasion, extravasation at sites of metastasis, and maintenance of the cancer stem cell phenotype that is required to generate secondary tumors. Recent preclinical studies suggest that the combination of cytotoxic chemotherapy with drugs that inhibit hypoxia-inducible factors may improve outcome for women with triple-negative breast cancer. This article is part of a Special Issue entitled: Tumor Microenvironment Regulation of Cancer Cell Survival, Metastasis, Inflammation, and Immune Surveillance edited by Peter Ruvolo and Gregg L. Semenza.
KW - Bone metastasis
KW - Lung metastasis
KW - Lymph node metastasis
KW - Mesenchymal stem cells
KW - Microvesicles
KW - Myeloid-derived suppressor cells
KW - Tumor-associated macrophages
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U2 - 10.1016/j.bbamcr.2015.05.036
DO - 10.1016/j.bbamcr.2015.05.036
M3 - Review article
C2 - 26079100
AN - SCOPUS:84955192227
SN - 0167-4889
VL - 1863
SP - 382
EP - 391
JO - Biochimica et Biophysica Acta - Molecular Cell Research
JF - Biochimica et Biophysica Acta - Molecular Cell Research
IS - 3
ER -